WormBase Tree Display for Gene: WBGene00001400
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| WBGene00001400 | SMap | S_parent | Sequence | F56E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fax-1 | Person_evidence | WBPerson691 | |||||
| Sequence_name | F56E3.4 | ||||||||
| Molecular_name | F56E3.4a | ||||||||
| F56E3.4a.1 | |||||||||
| CE28464 | |||||||||
| F56E3.4b | |||||||||
| CE04670 | |||||||||
| F56E3.4b.1 | |||||||||
| Other_name | nhr-29 | ||||||||
| CELE_F56E3.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | fax-1 | ||||||||
| DB_info | Database | AceView | gene | XD816 | |||||
| WormQTL | gene | WBGene00001400 | |||||||
| WormFlux | gene | WBGene00001400 | |||||||
| NDB | locus_tag | CELE_F56E3.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001400|UniProtKB=G5EDJ0 | |||||||
| family | PTHR24083 | ||||||||
| NCBI | gene | 180609 | |||||||
| RefSeq | protein | NM_001277024.2 | |||||||
| NM_076146.4 | |||||||||
| SwissProt | UniProtAcc | G5EDJ0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EDJ0 | |||||||
| OMIM | gene | 604485 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fax | ||||||||
| Allele (57) | |||||||||
| Legacy_information | [Wightman B] Mutations cause a weak kinker phenotype and defects in axon guidance of HSNL, AVKR, PVQL axons. | ||||||||
| [Wightman B] encoded by F56E3.4 nuclear hormone receptor, mutants are Unc, egg-laying constitutive, and have defects in axon pathfinding in the ventral nerve cord. | |||||||||
| Strain | WBStrain00027632 | ||||||||
| WBStrain00001394 | |||||||||
| WBStrain00027630 | |||||||||
| WBStrain00028736 | |||||||||
| WBStrain00028744 | |||||||||
| WBStrain00031525 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (43) | |||||||||
| Structured_description | Concise_description | fax-1 encodes a conserved nuclear receptor that contains two C4-type zinc fingers and is orthologous to the vertebrate photoreceptor-specific nuclear receptor PNR (OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); fax-1 is required for normal locomotion and neuron fate specification, including specification of the AVA, AVE, and AVK interneurons and proper axon pathfinding of the AVK, HSNL, and PVQL axons; expression of reporter gene fusions in fax-1 mutants suggests that fax-1 functions by regulating expression of a number of downstream targets, including nmr-1 and nmr-2, opt-3, flp-1, and ncs-1; in some neurons, fax-1 regulates expression combinatorially with unc-42, which encodes a paired-like homeodomain protein that additionally, regulates fax-1 expression in AVK neurons; FAX-1 exhibits sequence-specific DNA binding in vitro and the FAX-1 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; FAX-1 is expressed in the nuclei of 18 neurons, including the AVK, AVA, AVB, and AVE interneurons, beginning at mid-embryogenesis and continuing through larval and adult stages; FAX-1 is also seen in two non-neuronal cell types: the distal tip cells (DTCs), from L2 to L4 larval stages, and two pairs of vulval cells in L4 animals. | Paper_evidence | WBPaper00003941 | |||||
| WBPaper00026828 | |||||||||
| WBPaper00031380 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in several structures, including CEP; hermaphrodite distal tip cell; interneuron; pharyngeal motor neurons; and rect_D. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is an ortholog of human NR2E3 (nuclear receptor subfamily 2 group E member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0090059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||||
| DOID:0110399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||||||
| Molecular_info | Corresponding_CDS | F56E3.4a | |||||||
| F56E3.4b | |||||||||
| Corresponding_transcript | F56E3.4a.1 | ||||||||
| F56E3.4b.1 | |||||||||
| Other_sequence | SRC02099_1 | ||||||||
| Acan_isotig10071 | |||||||||
| EY464040.1 | |||||||||
| SR01788 | |||||||||
| FC815338.1 | |||||||||
| JI475021.1 | |||||||||
| CRC12381_1 | |||||||||
| JI170219.1 | |||||||||
| Associated_feature (11) | |||||||||
| Transcription_factor | WBTranscriptionFactor000521 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00027911 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00048731 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115862 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015835 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048732 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015837 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002284 | ||||||||
| WBCnstr00004291 | |||||||||
| WBCnstr00012731 | |||||||||
| WBCnstr00013827 | |||||||||
| WBCnstr00036970 | |||||||||
| Construct_product | WBCnstr00013827 | ||||||||
| WBCnstr00021906 | |||||||||
| WBCnstr00036970 | |||||||||
| Antibody | WBAntibody00000945 | ||||||||
| WBAntibody00002352 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (20) | |||||||||
| Map_info | Map | X | Position | -10.7537 | Error | 0.119879 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | syDf1 | |||||||
| yDp14 | |||||||||
| Positive_clone | C02A6 | Author_evidence | Wightman BC | ||||||
| C38F12 | Author_evidence | Wightman BC | |||||||
| F56E3 | Author_evidence | Wightman BC | |||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| W05A4 | Author_evidence | Wightman BC | |||||||
| Negative | Negative_clone | C15C7 | Author_evidence | Wightman BC | |||||
| F28B4 | Author_evidence | Wightman BC | |||||||
| F40F4 | Author_evidence | Wightman BC | |||||||
| Mapping_data | Multi_point | 3537 | |||||||
| 3538 | |||||||||
| 3539 | |||||||||
| 3696 | |||||||||
| 5603 | |||||||||
| Pos_neg_data | 9117 | ||||||||
| 9118 | |||||||||
| Reference (56) | |||||||||
| Method | Gene |
