WormBase Tree Display for Gene: WBGene00003657
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| WBGene00003657 | Evidence | Paper_evidence | WBPaper00003416 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C08F8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | nhr-67 | Person_evidence | WBPerson600 | |||||
| Sequence_name | C08F8.8 | ||||||||
| Molecular_name | C08F8.8 | ||||||||
| C08F8.8.1 | |||||||||
| CE18491 | |||||||||
| Other_name | lsy-9 | Person_evidence | WBPerson260 | ||||||
| CELE_C08F8.8 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | nhr-67 | ||||||||
| DB_info | Database | AceView | gene | 4L939 | |||||
| WormQTL | gene | WBGene00003657 | |||||||
| WormFlux | gene | WBGene00003657 | |||||||
| NDB | locus_tag | CELE_C08F8.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003657|UniProtKB=Q9XVV3 | |||||||
| family | PTHR24083 | ||||||||
| NCBI | gene | 178024 | |||||||
| RefSeq | protein | NM_069693.5 | |||||||
| SwissProt | UniProtAcc | Q9XVV3 | |||||||
| TREEFAM | TREEFAM_ID | TF315716 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XVV3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 25 Sep 2009 16:20:23 | WBPerson1847 | Event | Acquires_merge | WBGene00045430 | ||||
| Acquires_merge | WBGene00045430 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (77) | |||||||||
| Possibly_affected_by | WBVar02154069 | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (43) | |||||||||
| Structured_description | Concise_description | nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; NHR-67 exhibits sequence-specific DNA binding in vitro and the NHR-67 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell. | Paper_evidence | WBPaper00006412 | |||||
| WBPaper00029327 | |||||||||
| WBPaper00031380 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; negative regulation of G1/S transition of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory cell; head ganglion; neurons; rectal valve cell; and vulval cell. Is an ortholog of human NR2E1 (nuclear receptor subfamily 2 group E member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C08F8.8 | |||||||
| Corresponding_transcript | C08F8.8.1 | ||||||||
| Other_sequence | Acan_isotig03064 | ||||||||
| EX549836.1 | |||||||||
| ACC12903_1 | |||||||||
| AE04275 | |||||||||
| Acan_isotig03065 | |||||||||
| JI176573.1 | |||||||||
| Acan_isotig03063 | |||||||||
| AYC04572_1 | |||||||||
| Associated_feature | WBsf646360 | ||||||||
| WBsf660690 | |||||||||
| WBsf978398 | |||||||||
| WBsf997784 | |||||||||
| WBsf997785 | |||||||||
| WBsf997786 | |||||||||
| WBsf997787 | |||||||||
| WBsf1018181 | |||||||||
| WBsf229112 | |||||||||
| WBsf229113 | |||||||||
| Gene_product_binds (73) | |||||||||
| Transcription_factor | WBTranscriptionFactor000194 | ||||||||
| Experimental_info | RNAi_result (48) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product | WBCnstr00006618 | ||||||||
| WBCnstr00013524 | |||||||||
| WBCnstr00014193 | |||||||||
| WBCnstr00017316 | |||||||||
| WBCnstr00021188 | |||||||||
| WBCnstr00035966 | |||||||||
| WBCnstr00038773 | |||||||||
| WBCnstr00042251 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (150) | |||||||||
| Map_info | Map | IV | Position | 4.91863 | Error | 0.000847 | |||
| Positive | Positive_clone | C08F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4386 | |||||||
| 4526 | |||||||||
| 4609 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (59) | |||||||||
| Remark | yk273f2 (est clone is bimolecular) [Sluder A][030102 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
