WormBase Tree Display for Gene: WBGene00003657
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WBGene00003657 | Evidence | Paper_evidence | WBPaper00003416 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C08F8 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | nhr-67 | Person_evidence | WBPerson600 | |||
Sequence_name | C08F8.8 | ||||||
Molecular_name | C08F8.8 | ||||||
C08F8.8.1 | |||||||
CE18491 | |||||||
Other_name | lsy-9 | Person_evidence | WBPerson260 | ||||
CELE_C08F8.8 | Accession_evidence | NDB | BX284604 | ||||
Public_name | nhr-67 | ||||||
DB_info | Database | AceView | gene | 4L939 | |||
WormQTL | gene | WBGene00003657 | |||||
WormFlux | gene | WBGene00003657 | |||||
NDB | locus_tag | CELE_C08F8.8 | |||||
Panther | gene | CAEEL|WormBase=WBGene00003657|UniProtKB=Q9XVV3 | |||||
family | PTHR24083 | ||||||
NCBI | gene | 178024 | |||||
RefSeq | protein | NM_069693.5 | |||||
SwissProt | UniProtAcc | Q9XVV3 | |||||
TREEFAM | TREEFAM_ID | TF315716 | |||||
UniProt_GCRP | UniProtAcc | Q9XVV3 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nhr | ||||||
Allele (77) | |||||||
Possibly_affected_by | WBVar02154069 | ||||||
Strain (15) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (29) | |||||||
Ortholog (44) | |||||||
Paralog (43) | |||||||
Structured_description | Concise_description | nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; NHR-67 exhibits sequence-specific DNA binding in vitro and the NHR-67 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell. | Paper_evidence | WBPaper00006412 | |||
WBPaper00029327 | |||||||
WBPaper00031380 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 09 Oct 2008 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; negative regulation of G1/S transition of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory cell; head ganglion; neurons; rectal valve cell; and vulval cell. Is an ortholog of human NR2E1 (nuclear receptor subfamily 2 group E member 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C08F8.8 | |||||
Corresponding_transcript | C08F8.8.1 | ||||||
Other_sequence | Acan_isotig03064 | ||||||
EX549836.1 | |||||||
ACC12903_1 | |||||||
AE04275 | |||||||
Acan_isotig03065 | |||||||
JI176573.1 | |||||||
Acan_isotig03063 | |||||||
AYC04572_1 | |||||||
Associated_feature | WBsf646360 | ||||||
WBsf660690 | |||||||
WBsf978398 | |||||||
WBsf997784 | |||||||
WBsf997785 | |||||||
WBsf997786 | |||||||
WBsf997787 | |||||||
WBsf1018181 | |||||||
WBsf229112 | |||||||
WBsf229113 | |||||||
Gene_product_binds (73) | |||||||
Transcription_factor | WBTranscriptionFactor000194 | ||||||
Experimental_info | RNAi_result (48) | ||||||
Expr_pattern (18) | |||||||
Drives_construct (18) | |||||||
Construct_product | WBCnstr00006618 | ||||||
WBCnstr00013524 | |||||||
WBCnstr00014193 | |||||||
WBCnstr00017316 | |||||||
WBCnstr00021188 | |||||||
WBCnstr00035966 | |||||||
WBCnstr00038773 | |||||||
WBCnstr00042251 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (154) | |||||||
Interaction (150) | |||||||
Map_info | Map | IV | Position | 4.91863 | Error | 0.000847 | |
Positive | Positive_clone | C08F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4386 | |||||
4526 | |||||||
4609 | |||||||
Pseudo_map_position | |||||||
Reference (59) | |||||||
Remark | yk273f2 (est clone is bimolecular) [Sluder A][030102 ck1] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |