WormBase Tree Display for Gene: WBGene00003657

WBGene00003657 Evidence: Paper_evidence: WBPaper00003416
  SMap: S_parent: Sequence: C08F8
  Identity: Version: 2
    Name: CGC_name: nhr-67 Person_evidence: WBPerson600
      Sequence_name: C08F8.8
      Molecular_name: C08F8.8
        C08F8.8.1
        CE18491
      Other_name: lsy-9 Person_evidence: WBPerson260
        CELE_C08F8.8 Accession_evidence: NDB BX284604
      Public_name: nhr-67
    DB_info: Database: AceView gene 4L939
        WormQTL gene WBGene00003657
        WormFlux gene WBGene00003657
        NDB locus_tag CELE_C08F8.8
        Panther gene CAEEL|WormBase=WBGene00003657|UniProtKB=Q9XVV3
          family PTHR24083
        NCBI gene 178024
        RefSeq protein NM_069693.5
        SwissProt UniProtAcc Q9XVV3
        TREEFAM TREEFAM_ID TF315716
        UniProt_GCRP UniProtAcc Q9XVV3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 25 Sep 2009 16:20:23 WBPerson1847 Event: Acquires_merge: WBGene00045430
      Acquires_merge: WBGene00045430
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhr
    Allele (77)
    Possibly_affected_by: WBVar02154069
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (44)
    Paralog (43)
    Structured_description: Concise_description: nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; NHR-67 exhibits sequence-specific DNA binding in vitro and the NHR-67 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell. Paper_evidence: WBPaper00006412
            WBPaper00029327
            WBPaper00031380
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Oct 2008 00:00:00
      Automated_description: Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; negative regulation of G1/S transition of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory cell; head ganglion; neurons; rectal valve cell; and vulval cell. Is an ortholog of human NR2E1 (nuclear receptor subfamily 2 group E member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C08F8.8
    Corresponding_transcript: C08F8.8.1
    Other_sequence: Acan_isotig03064
      EX549836.1
      ACC12903_1
      AE04275
      Acan_isotig03065
      JI176573.1
      Acan_isotig03063
      AYC04572_1
    Associated_feature: WBsf646360
      WBsf660690
      WBsf978398
      WBsf997784
      WBsf997785
      WBsf997786
      WBsf997787
      WBsf1018181
      WBsf229112
      WBsf229113
    Gene_product_binds (73)
    Transcription_factor: WBTranscriptionFactor000194
  Experimental_info: RNAi_result (48)
    Expr_pattern (18)
    Drives_construct (18)
    Construct_product: WBCnstr00006618
      WBCnstr00013524
      WBCnstr00014193
      WBCnstr00017316
      WBCnstr00021188
      WBCnstr00035966
      WBCnstr00038773
      WBCnstr00042251
    Microarray_results (20)
    Expression_cluster (154)
    Interaction: WBInteraction000009708
      WBInteraction000009711
      WBInteraction000009932
      WBInteraction000029469
      WBInteraction000029788
      WBInteraction000031384
      WBInteraction000031385
      WBInteraction000033161
      WBInteraction000033568
      WBInteraction000034405
      WBInteraction000039623
      WBInteraction000041776
      WBInteraction000042465
      WBInteraction000045983
      WBInteraction000045984
      WBInteraction000046097
      WBInteraction000046098
      WBInteraction000047182
      WBInteraction000047258
      WBInteraction000047498
      WBInteraction000049579
      WBInteraction000049743
      WBInteraction000050599
      WBInteraction000050600
      WBInteraction000050601
      WBInteraction000050602
      WBInteraction000050603
      WBInteraction000050604
      WBInteraction000052721
      WBInteraction000052722
      WBInteraction000052723
      WBInteraction000052972
      WBInteraction000196026
      WBInteraction000208369
      WBInteraction000328513
      WBInteraction000330776
      WBInteraction000330993
      WBInteraction000331742
      WBInteraction000333345
      WBInteraction000350550
      WBInteraction000359634
      WBInteraction000364325
      WBInteraction000370412
      WBInteraction000370454
      WBInteraction000375668
      WBInteraction000378654
      WBInteraction000380235
      WBInteraction000381134
      WBInteraction000384254
      WBInteraction000384255
      WBInteraction000385488
      WBInteraction000397413
      WBInteraction000397806
      WBInteraction000400498
      WBInteraction000407080
      WBInteraction000409933
      WBInteraction000414110
      WBInteraction000417279
      WBInteraction000418700
      WBInteraction000421641
      WBInteraction000423859
      WBInteraction000427008
      WBInteraction000431673
      WBInteraction000439591
      WBInteraction000440644
      WBInteraction000441804
      WBInteraction000448034
      WBInteraction000450489
      WBInteraction000452860
      WBInteraction000455937
      WBInteraction000501323
      WBInteraction000502881
      WBInteraction000502882
      WBInteraction000502886
      WBInteraction000502887
      WBInteraction000502889
      WBInteraction000502890
      WBInteraction000502891
      WBInteraction000502892
      WBInteraction000503854
      WBInteraction000504024
      WBInteraction000504025
      WBInteraction000504096
      WBInteraction000504097
      WBInteraction000504098
      WBInteraction000504941
      WBInteraction000505444
      WBInteraction000506507
      WBInteraction000506508
      WBInteraction000506509
      WBInteraction000506510
      WBInteraction000506511
      WBInteraction000506512
      WBInteraction000506513
      WBInteraction000506514
      WBInteraction000506515
      WBInteraction000506516
      WBInteraction000506517
      WBInteraction000506518
      WBInteraction000512385
      WBInteraction000512386
      WBInteraction000512387
      WBInteraction000512388
      WBInteraction000512389
      WBInteraction000512390
      WBInteraction000512392
      WBInteraction000512393
      WBInteraction000512394
      WBInteraction000512395
      WBInteraction000512396
      WBInteraction000520393
      WBInteraction000525559
      WBInteraction000525577
      WBInteraction000525741
      WBInteraction000525754
      WBInteraction000525771
      WBInteraction000525811
      WBInteraction000525843
      WBInteraction000525889
      WBInteraction000526018
      WBInteraction000526062
      WBInteraction000526098
      WBInteraction000526381
      WBInteraction000526443
      WBInteraction000526622
      WBInteraction000526964
      WBInteraction000527042
      WBInteraction000527071
      WBInteraction000527105
      WBInteraction000527220
      WBInteraction000527293
      WBInteraction000527450
      WBInteraction000527569
      WBInteraction000527726
      WBInteraction000527794
      WBInteraction000527815
      WBInteraction000527892
      WBInteraction000528014
      WBInteraction000528888
      WBInteraction000529331
      WBInteraction000533528
      WBInteraction000533604
      WBInteraction000533927
      WBInteraction000534188
      WBInteraction000534865
      WBInteraction000534866
      WBInteraction000535021
      WBInteraction000547212
      WBInteraction000586824
      WBInteraction000586825
  Map_info: Map: IV Position: 4.91863 Error: 0.000847
    Positive: Positive_clone: C08F8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4386
        4526
        4609
    Pseudo_map_position
  Reference (59)
  Remark: yk273f2 (est clone is bimolecular) [Sluder A][030102 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene