WormBase Tree Display for Gene: WBGene00003659
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WBGene00003659 | SMap | S_parent | Sequence | T23H4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | nhr-69 | Person_evidence | WBPerson600 | |||||
Sequence_name | T23H4.2 | ||||||||
Molecular_name | T23H4.2 | ||||||||
T23H4.2.1 | |||||||||
CE32501 | |||||||||
Other_name | CELE_T23H4.2 | Accession_evidence | NDB | BX284601 | |||||
Public_name | nhr-69 | ||||||||
DB_info | Database | AceView | gene | 1K456 | |||||
WormQTL | gene | WBGene00003659 | |||||||
WormFlux | gene | WBGene00003659 | |||||||
NDB | locus_tag | CELE_T23H4.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003659|UniProtKB=P91829 | |||||||
family | PTHR24083 | ||||||||
NCBI | gene | 172840 | |||||||
RefSeq | protein | NM_060214.5 | |||||||
SwissProt | UniProtAcc | P91829 | |||||||
UniProt_GCRP | UniProtAcc | P91829 | |||||||
OMIM | gene | 600281 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | nhr | ||||||||
Allele (33) | |||||||||
Strain | WBStrain00032274 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog (45) | |||||||||
Paralog (42) | |||||||||
Structured_description | Concise_description | nhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx. | Paper_evidence | WBPaper00006412 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables SMAD binding activity and steroid hormone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ASI; hypodermis; intestine; tail neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0111099 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:9993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
DOID:0080760 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
Molecular_info | Corresponding_CDS | T23H4.2 | |||||||
Corresponding_CDS_history | T23H4.2:wp90 | ||||||||
Corresponding_transcript | T23H4.2.1 | ||||||||
Other_sequence (29) | |||||||||
Associated_feature | WBsf655304 | ||||||||
WBsf664798 | |||||||||
WBsf978741 | |||||||||
WBsf984843 | |||||||||
WBsf1010449 | |||||||||
Transcription_factor | WBTranscriptionFactor000195 | ||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00010995 | ||||||||
WBCnstr00014433 | |||||||||
WBCnstr00015297 | |||||||||
WBCnstr00015298 | |||||||||
WBCnstr00015299 | |||||||||
WBCnstr00035964 | |||||||||
Construct_product | WBCnstr00014433 | ||||||||
WBCnstr00014435 | |||||||||
WBCnstr00035964 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (113) | |||||||||
Interaction (52) | |||||||||
Map_info | Map | I | Position | 3.97675 | Error | 0.001387 | |||
Positive | Positive_clone | T23H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (15) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |