WormBase Tree Display for Gene: WBGene00003659
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| WBGene00003659 | SMap | S_parent | Sequence | T23H4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhr-69 | Person_evidence | WBPerson600 | |||||
| Sequence_name | T23H4.2 | ||||||||
| Molecular_name | T23H4.2 | ||||||||
| T23H4.2.1 | |||||||||
| CE32501 | |||||||||
| Other_name | CELE_T23H4.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | nhr-69 | ||||||||
| DB_info | Database | AceView | gene | 1K456 | |||||
| WormQTL | gene | WBGene00003659 | |||||||
| WormFlux | gene | WBGene00003659 | |||||||
| NDB | locus_tag | CELE_T23H4.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003659|UniProtKB=P91829 | |||||||
| family | PTHR24083 | ||||||||
| NCBI | gene | 172840 | |||||||
| RefSeq | protein | NM_060214.5 | |||||||
| SwissProt | UniProtAcc | P91829 | |||||||
| UniProt_GCRP | UniProtAcc | P91829 | |||||||
| OMIM | gene | 600281 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00032274 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (42) | |||||||||
| Structured_description | Concise_description | nhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx. | Paper_evidence | WBPaper00006412 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables SMAD binding activity and steroid hormone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ASI; hypodermis; intestine; tail neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111099 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
| DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:9993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| DOID:0080760 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||||
| Molecular_info | Corresponding_CDS | T23H4.2 | |||||||
| Corresponding_CDS_history | T23H4.2:wp90 | ||||||||
| Corresponding_transcript | T23H4.2.1 | ||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf655304 | ||||||||
| WBsf664798 | |||||||||
| WBsf978741 | |||||||||
| WBsf984843 | |||||||||
| WBsf1010449 | |||||||||
| Transcription_factor | WBTranscriptionFactor000195 | ||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00010995 | ||||||||
| WBCnstr00014433 | |||||||||
| WBCnstr00015297 | |||||||||
| WBCnstr00015298 | |||||||||
| WBCnstr00015299 | |||||||||
| WBCnstr00035964 | |||||||||
| Construct_product | WBCnstr00014433 | ||||||||
| WBCnstr00014435 | |||||||||
| WBCnstr00035964 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction | WBInteraction000029425 | ||||||||
| WBInteraction000031386 | |||||||||
| WBInteraction000031387 | |||||||||
| WBInteraction000217997 | |||||||||
| WBInteraction000219438 | |||||||||
| WBInteraction000234841 | |||||||||
| WBInteraction000265821 | |||||||||
| WBInteraction000278836 | |||||||||
| WBInteraction000280858 | |||||||||
| WBInteraction000384517 | |||||||||
| WBInteraction000407493 | |||||||||
| WBInteraction000429363 | |||||||||
| WBInteraction000449761 | |||||||||
| WBInteraction000505308 | |||||||||
| WBInteraction000505378 | |||||||||
| WBInteraction000507959 | |||||||||
| WBInteraction000507962 | |||||||||
| WBInteraction000507963 | |||||||||
| WBInteraction000507964 | |||||||||
| WBInteraction000507965 | |||||||||
| WBInteraction000507966 | |||||||||
| WBInteraction000507967 | |||||||||
| WBInteraction000507968 | |||||||||
| WBInteraction000507969 | |||||||||
| WBInteraction000507970 | |||||||||
| WBInteraction000507971 | |||||||||
| WBInteraction000507972 | |||||||||
| WBInteraction000507973 | |||||||||
| WBInteraction000507977 | |||||||||
| WBInteraction000507978 | |||||||||
| WBInteraction000507979 | |||||||||
| WBInteraction000507980 | |||||||||
| WBInteraction000507981 | |||||||||
| WBInteraction000507982 | |||||||||
| WBInteraction000514699 | |||||||||
| WBInteraction000514700 | |||||||||
| WBInteraction000517405 | |||||||||
| WBInteraction000517406 | |||||||||
| WBInteraction000527017 | |||||||||
| WBInteraction000527237 | |||||||||
| WBInteraction000528749 | |||||||||
| WBInteraction000530491 | |||||||||
| WBInteraction000530622 | |||||||||
| WBInteraction000530942 | |||||||||
| WBInteraction000531425 | |||||||||
| WBInteraction000532142 | |||||||||
| WBInteraction000534598 | |||||||||
| WBInteraction000548470 | |||||||||
| WBInteraction000548953 | |||||||||
| WBInteraction000550815 | |||||||||
| WBInteraction000555254 | |||||||||
| WBInteraction000560747 | |||||||||
| Map_info | Map | I | Position | 3.97675 | Error | 0.001387 | |||
| Positive | Positive_clone | T23H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
