Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00003659

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00003659SMapS_parentSequenceT23H4
IdentityVersion1
NameCGC_namenhr-69Person_evidenceWBPerson600
Sequence_nameT23H4.2
Molecular_nameT23H4.2
T23H4.2.1
CE32501
Other_nameCELE_T23H4.2Accession_evidenceNDBBX284601
Public_namenhr-69
DB_infoDatabaseAceViewgene1K456
WormQTLgeneWBGene00003659
WormFluxgeneWBGene00003659
NDBlocus_tagCELE_T23H4.2
PanthergeneCAEEL|WormBase=WBGene00003659|UniProtKB=P91829
familyPTHR24083
NCBIgene172840
RefSeqproteinNM_060214.5
SwissProtUniProtAccP91829
UniProt_GCRPUniProtAccP91829
OMIMgene600281
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (33)
StrainWBStrain00032274
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (45)
ParalogWBGene00001400Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003613Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003616Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003627Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003628Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003639Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003650Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003654Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003657Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003681Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00021417Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015497Caenorhabditis elegansFrom_analysisPanther
WBGene00021848Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003701Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003710Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015705Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00020748Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017198Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003726Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00007546Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017787Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00008221Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00011099Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00011098Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00011097Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00007547Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015396Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003719Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015395Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003706Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00011100Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003727Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00016975Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003708Caenorhabditis elegansFrom_analysisPanther
WBGene00003690Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003626Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003678Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003683Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015397Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019816Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00022423Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00044354Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionnhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx.Paper_evidenceWBPaper00006412
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables SMAD binding activity and steroid hormone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ASI; hypodermis; intestine; tail neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Molecular_infoCorresponding_CDST23H4.2
Corresponding_CDS_historyT23H4.2:wp90
Corresponding_transcriptT23H4.2.1
Other_sequence (29)
Associated_featureWBsf655304
WBsf664798
WBsf978741
WBsf984843
WBsf1010449
Transcription_factorWBTranscriptionFactor000195
Experimental_infoRNAi_result (11)
Expr_pattern (12)
Drives_constructWBCnstr00010995
WBCnstr00014433
WBCnstr00015297
WBCnstr00015298
WBCnstr00015299
WBCnstr00035964
Construct_productWBCnstr00014433
WBCnstr00014435
WBCnstr00035964
Microarray_results (19)
Expression_cluster (113)
Interaction (52)
Map_infoMapIPosition3.97675Error0.001387
PositivePositive_cloneT23H4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (15)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene