WormBase Tree Display for Gene: WBGene00008681

WBGene00008681 SMap: S_parent: Sequence: F11A6
  Identity: Version: 3
    Name: CGC_name: scrm-4 Paper_evidence: WBPaper00029228
          Person_evidence: WBPerson1606
      Sequence_name: F11A6.2
      Molecular_name: F11A6.2
        F11A6.2.1
        CE41222
      Other_name: plsc-4 Person_evidence: WBPerson1626
        CELE_F11A6.2 Accession_evidence: NDB BX284601
      Public_name: scrm-4
    DB_info: Database: AceView gene 1M270
        WormQTL gene WBGene00008681
        WormFlux gene WBGene00008681
        NDB locus_tag CELE_F11A6.2
        Panther gene CAEEL|WormBase=WBGene00008681|UniProtKB=O62149
          family PTHR23248
        NCBI gene 184340
        RefSeq protein NM_060574.5
        TREEFAM TREEFAM_ID TF314939
        TrEMBL UniProtAcc O62149
        UniProt_GCRP UniProtAcc O62149
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 16 Oct 2006 17:00:28 WBPerson2970 Name_change: CGC_name: plsc-4
        3 03 May 2007 10:33:07 WBPerson2970 Name_change: CGC_name: scrm-4
                Other_name: plsc-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scrm
    Allele (34)
    Strain: WBStrain00033259
      WBStrain00033272
    RNASeq_FPKM (74)
    GO_annotation: 00037188
      00037189
      00037190
      00116557
      00116558
    Ortholog (35)
    Paralog: WBGene00014200 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00011935 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015437 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009753 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019531 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013052 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019530 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00235369 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: scrm-4 encodes a putative phospholipid scramblase homologous to humanPLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1); inapoptotic germline cells, SCRM-4 is fully dispensable for normally rapidengulfment and largely dispensable for phosphatidylserine exposure;SCRM-4 does not bind WAH-1 in vitro, and scrm-4(tm624) mutants have noobvious phenotype. Paper_evidence: WBPaper00004911
            WBPaper00012809
            WBPaper00013208
            WBPaper00013590
            WBPaper00029228
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 May 2007 00:00:00
      Automated_description: Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be located in plasma membrane. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F11A6.2
    Corresponding_CDS_history: F11A6.2:wp114
      F11A6.2:wp177
    Corresponding_transcript: F11A6.2.1
    Associated_feature: WBsf220358
  Experimental_info: RNAi_result: WBRNAi00030813 Inferred_automatically: RNAi_primary
      WBRNAi00062200 Inferred_automatically: RNAi_primary
      WBRNAi00044359 Inferred_automatically: RNAi_primary
      WBRNAi00097538 Inferred_automatically: RNAi_primary
      WBRNAi00003364 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012624
      Expr1033778
      Expr1148299
      Expr2015653
      Expr2033885
    Drives_construct: WBCnstr00032775
    Construct_product: WBCnstr00032775
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:Cluster_4
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00036231:long-telomeres_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00040560:hpl-2_L3_upregulated
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044736:flat_dev_expression
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046212:HeatStress_heritably_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_upregulated_protein
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049098:heat-induced_N2
      WBPaper00049098:hrde-1(tm1200)-induced_15C
      WBPaper00049098:hrde-1(tm1200)-induced_23C
      WBPaper00049098:hrde-1(tm1200)-induced_p15C
      WBPaper00049134:hpk-1(pk1393)_downregulated
      WBPaper00049177:rpn-10(ok1865)_upregulated
      WBPaper00049368:daf-2(e1370)_upregulated
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00050094:glp-1(gf)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050504:hrp-2(RNAi)_upregulated
      WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051338:jmjd-5(tm3735)_upregulated_G0
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052885:hrde-1(tm1200)-emb-4(qm31)_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:25C_upregulated_OP50
      WBPaper00053814:25C_upregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00054571:BPA_F3_germline_downregulated
      WBPaper00054571:BPA_F3_germline_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055226:adr-1(tm668)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055364:uaf-1(n4588)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057140:pptr-1(tm3103)_downregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00057162:meg-3_meg-4_downregulated_sRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058925:acox-1.1(ok2257)_upregulated
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059605:simr-1(cmp36)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00060951:mrpl-2(osa3)_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:hrde-1(tm1200)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:C10C5.2-Y58A7A.3
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062118:neural-HSF-1_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062606:rotenone_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064473:ets-4(rrr16)_upregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064850:glh-1(sam65)_downregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065132:asna-1(ok938)_upregulated_protein
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00066004:ceh-14(ch3)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952)
      WBPaper00066163:set-2(ok952)_upregulated_N2
      WBPaper00066204:CdCl2_upregulated_mRNA
      cgc4489_group_8
      WBPaper00025032:cluster_179
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00028483:Up_mes-4_vs_WT
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031477:Up_deps-1_vs_WT
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00033101:spr-5_regulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036429:glp-1(oz112)_upregulated
      WBPaper00037695:CC_3-day
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040184:hcf-1up_sir-2.1down_daf-2up
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA100_up
      WBPaper00040963:TA300_up
      WBPaper00041174:environmental
      WBPaper00041174:genotype_environment_interaction
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:mixed_oogenesis-somatic
    Interaction: WBInteraction000050587
      WBInteraction000187215
      WBInteraction000366772
      WBInteraction000456427
      WBInteraction000580606
  Map_info: Map: I Position: 9.55039 Error: 0.005902
    Positive: Positive_clone: F11A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00028483
    WBPaper00028527
    WBPaper00029228
    WBPaper00030738
    WBPaper00032961
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00058537
    WBPaper00063045
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene