WormBase Tree Display for Gene: WBGene00011935
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| WBGene00011935 | SMap | S_parent | Sequence | T22H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | scrm-1 | Paper_evidence | WBPaper00029228 | |||||
| Person_evidence | WBPerson1606 | ||||||||
| Sequence_name | T22H2.5 | ||||||||
| Molecular_name | T22H2.5a | ||||||||
| T22H2.5a.1 | |||||||||
| CE36204 | |||||||||
| T22H2.5b | |||||||||
| CE36205 | |||||||||
| T22H2.5c | |||||||||
| CE46345 | |||||||||
| T22H2.5a.2 | |||||||||
| T22H2.5b.1 | |||||||||
| T22H2.5c.1 | |||||||||
| Other_name | plsc-2 | Person_evidence | WBPerson1626 | ||||||
| CELE_T22H2.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | scrm-1 | ||||||||
| DB_info | Database | AceView | gene | 1M282 | |||||
| WormQTL | gene | WBGene00011935 | |||||||
| WormFlux | gene | WBGene00011935 | |||||||
| NDB | locus_tag | CELE_T22H2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011935|UniProtKB=O45799 | |||||||
| family | PTHR23248 | ||||||||
| NCBI | gene | 173053 | |||||||
| RefSeq | protein | NM_001392951.1 | |||||||
| NM_001264776.4 | |||||||||
| NM_060575.6 | |||||||||
| TREEFAM | TREEFAM_ID | TF314939 | |||||||
| TrEMBL | UniProtAcc | G3MU68 | |||||||
| O45799 | |||||||||
| Q7JKP1 | |||||||||
| UniProt_GCRP | UniProtAcc | O45799 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 16 Oct 2006 17:00:28 | WBPerson2970 | Name_change | CGC_name | plsc-2 | ||||
| 3 | 03 May 2007 10:33:07 | WBPerson2970 | Name_change | CGC_name | scrm-1 | ||||
| Other_name | plsc-2 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | scrm | ||||||||
| Allele (55) | |||||||||
| Strain | WBStrain00005192 | ||||||||
| WBStrain00005193 | |||||||||
| WBStrain00047218 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (54) | |||||||||
| Paralog | WBGene00008681 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009753 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00014200 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015437 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019530 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019531 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013052 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00235369 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | scrm-1 encodes, by alternative splicing, two isoforms of a putativephospholipid scramblase required for phosphatidylserine exposure and thenormally rapid engulfment of apoptotic cells in the germline; SCRM-1 islocalized to plasma membranes of embryonic cells from earlyembryogenesis onward; SCRM-1 is specifically bound by residues 380-550of WAH-1 in vitro, and WAH-1 binding is required in liposomes for morethan residual SCRM-1 activity; in scrm-1(tm698) or scrm-1(tm805)embryos, apoptotic cells do eventually disappear, but their removal isdelayed; SCRM-1 is homologous to human PLSCR1-5, and paralogous toSCRM-2 through SCRM-8. | Paper_evidence | WBPaper00004911 | |||||
| WBPaper00012809 | |||||||||
| WBPaper00013208 | |||||||||
| WBPaper00013590 | |||||||||
| WBPaper00029228 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 16 May 2007 00:00:00 | ||||||||
| Automated_description | Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Expressed in several structures, including germ line. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T22H2.5a | |||||||
| T22H2.5b | |||||||||
| T22H2.5c | |||||||||
| Corresponding_CDS_history | T22H2.5a:wp114 | ||||||||
| T22H2.5b:wp114 | |||||||||
| Corresponding_transcript | T22H2.5a.1 | ||||||||
| T22H2.5a.2 | |||||||||
| T22H2.5b.1 | |||||||||
| T22H2.5c.1 | |||||||||
| Other_sequence | NBC07936_1 | ||||||||
| DN190196.1 | |||||||||
| Oden_isotig20045 | |||||||||
| NB06820 | |||||||||
| CBC00339_1 | |||||||||
| Oden_isotig22603 | |||||||||
| Acan_isotig11840 | |||||||||
| Oden_isotig22385 | |||||||||
| AAC00108_1 | |||||||||
| Associated_feature | WBsf716505 | ||||||||
| WBsf985363 | |||||||||
| WBsf985364 | |||||||||
| WBsf1010769 | |||||||||
| WBsf220359 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr4579 | ||||||||
| Expr1010600 | |||||||||
| Expr1035267 | |||||||||
| Expr1157415 | |||||||||
| Expr2015650 | |||||||||
| Expr2033882 | |||||||||
| Antibody | WBAntibody00001243 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (92) | |||||||||
| Map_info | Map | I | Position | 9.56187 | Error | 0.004742 | |||
| Positive | Positive_clone | T22H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
