WormBase Tree Display for Gene: WBGene00011935

WBGene00011935 SMap: S_parent: Sequence: T22H2
  Identity: Version: 3
    Name: CGC_name: scrm-1 Paper_evidence: WBPaper00029228
          Person_evidence: WBPerson1606
      Sequence_name: T22H2.5
      Molecular_name: T22H2.5a
        T22H2.5a.1
        CE36204
        T22H2.5b
        CE36205
        T22H2.5c
        CE46345
        T22H2.5a.2
        T22H2.5b.1
        T22H2.5c.1
      Other_name: plsc-2 Person_evidence: WBPerson1626
        CELE_T22H2.5 Accession_evidence: NDB BX284601
      Public_name: scrm-1
    DB_info: Database: AceView gene 1M282
        WormQTL gene WBGene00011935
        WormFlux gene WBGene00011935
        NDB locus_tag CELE_T22H2.5
        Panther gene CAEEL|WormBase=WBGene00011935|UniProtKB=O45799
          family PTHR23248
        NCBI gene 173053
        RefSeq protein NM_001392951.1
            NM_001264776.4
            NM_060575.6
        TREEFAM TREEFAM_ID TF314939
        TrEMBL UniProtAcc G3MU68
            O45799
            Q7JKP1
        UniProt_GCRP UniProtAcc O45799
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 16 Oct 2006 17:00:28 WBPerson2970 Name_change: CGC_name: plsc-2
        3 03 May 2007 10:33:07 WBPerson2970 Name_change: CGC_name: scrm-1
                Other_name: plsc-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scrm
    Allele (55)
    Strain: WBStrain00005192
      WBStrain00005193
      WBStrain00047218
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (54)
    Paralog: WBGene00008681 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009753 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00014200 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00015437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019530 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019531 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013052 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00235369 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: scrm-1 encodes, by alternative splicing, two isoforms of a putativephospholipid scramblase required for phosphatidylserine exposure and thenormally rapid engulfment of apoptotic cells in the germline; SCRM-1 islocalized to plasma membranes of embryonic cells from earlyembryogenesis onward; SCRM-1 is specifically bound by residues 380-550of WAH-1 in vitro, and WAH-1 binding is required in liposomes for morethan residual SCRM-1 activity; in scrm-1(tm698) or scrm-1(tm805)embryos, apoptotic cells do eventually disappear, but their removal isdelayed; SCRM-1 is homologous to human PLSCR1-5, and paralogous toSCRM-2 through SCRM-8. Paper_evidence: WBPaper00004911
            WBPaper00012809
            WBPaper00013208
            WBPaper00013590
            WBPaper00029228
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 May 2007 00:00:00
      Automated_description: Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Expressed in several structures, including germ line. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T22H2.5a
      T22H2.5b
      T22H2.5c
    Corresponding_CDS_history: T22H2.5a:wp114
      T22H2.5b:wp114
    Corresponding_transcript: T22H2.5a.1
      T22H2.5a.2
      T22H2.5b.1
      T22H2.5c.1
    Other_sequence: NBC07936_1
      DN190196.1
      Oden_isotig20045
      NB06820
      CBC00339_1
      Oden_isotig22603
      Acan_isotig11840
      Oden_isotig22385
      AAC00108_1
    Associated_feature: WBsf716505
      WBsf985363
      WBsf985364
      WBsf1010769
      WBsf220359
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr4579
      Expr1010600
      Expr1035267
      Expr1157415
      Expr2015650
      Expr2033882
    Antibody: WBAntibody00001243
    Microarray_results (30)
    Expression_cluster (146)
    Interaction: WBInteraction000029622
      WBInteraction000029656
      WBInteraction000029667
      WBInteraction000029915
      WBInteraction000031420
      WBInteraction000031954
      WBInteraction000032311
      WBInteraction000032319
      WBInteraction000032320
      WBInteraction000051057
      WBInteraction000051103
      WBInteraction000051149
      WBInteraction000051195
      WBInteraction000051241
      WBInteraction000051287
      WBInteraction000051333
      WBInteraction000152359
      WBInteraction000162661
      WBInteraction000167767
      WBInteraction000218050
      WBInteraction000384381
      WBInteraction000384554
      WBInteraction000387730
      WBInteraction000387754
      WBInteraction000387772
      WBInteraction000387776
      WBInteraction000387818
      WBInteraction000387866
      WBInteraction000387880
      WBInteraction000387912
      WBInteraction000387946
      WBInteraction000388000
      WBInteraction000388050
      WBInteraction000388066
      WBInteraction000388084
      WBInteraction000388088
      WBInteraction000388116
      WBInteraction000388131
      WBInteraction000388147
      WBInteraction000388148
      WBInteraction000388149
      WBInteraction000388150
      WBInteraction000388151
      WBInteraction000388152
      WBInteraction000388153
      WBInteraction000388154
      WBInteraction000388155
      WBInteraction000388156
      WBInteraction000388157
      WBInteraction000388158
      WBInteraction000388159
      WBInteraction000388209
      WBInteraction000388253
      WBInteraction000388322
      WBInteraction000388338
      WBInteraction000388342
      WBInteraction000388347
      WBInteraction000416982
      WBInteraction000417001
      WBInteraction000417002
      WBInteraction000506831
      WBInteraction000507406
      WBInteraction000508072
      WBInteraction000509106
      WBInteraction000509160
      WBInteraction000514812
      WBInteraction000514813
      WBInteraction000514814
      WBInteraction000514815
      WBInteraction000514816
      WBInteraction000514817
      WBInteraction000514818
      WBInteraction000514876
      WBInteraction000515636
      WBInteraction000522092
      WBInteraction000522115
      WBInteraction000522116
      WBInteraction000522117
      WBInteraction000522118
      WBInteraction000522119
      WBInteraction000522120
      WBInteraction000522121
      WBInteraction000522122
      WBInteraction000522145
      WBInteraction000522146
      WBInteraction000522147
      WBInteraction000522149
      WBInteraction000522150
      WBInteraction000546570
      WBInteraction000551094
      WBInteraction000555260
      WBInteraction000560481
  Map_info: Map: I Position: 9.56187 Error: 0.004742
    Positive: Positive_clone: T22H2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene