WBGene00006741 | SMap | S_parent | Sequence | K03E6 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-1 | Person_evidence | WBPerson261 |
| | | Sequence_name | K03E6.5 |
| | | Molecular_name | K03E6.5a |
| | | | K03E6.5a.1 |
| | | | CE28585 |
| | | | K03E6.5b |
| | | | CE42275 |
| | | | K03E6.5b.1 |
| | | Other_name | unc-102 |
| | | | CELE_K03E6.5 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-1 |
| | DB_info | Database | AceView | gene | XB678 |
| | | | WormQTL | gene | WBGene00006741 |
| | | | WormFlux | gene | WBGene00006741 |
| | | | NDB | locus_tag | CELE_K03E6.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006741|UniProtKB=Q21190 |
| | | | | family | PTHR10264 |
| | | | NCBI | gene | 180458 |
| | | | RefSeq | protein | NM_001129690.5 |
| | | | | | NM_075801.7 |
| | | | SwissProt | UniProtAcc | Q21190 |
| | | | TrEMBL | UniProtAcc | G5ED08 |
| | | | UniProt_GCRP | UniProtAcc | Q21190 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Allele (97) |
| | Legacy_information (4) |
| | Strain (37) |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog | WBGene00060181 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00029931 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00152750 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00128531 | Caenorhabditis japonica | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00225050 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g3363 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g14605 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g817 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g13383 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g540 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g6125 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP32.g16606 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g6046 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g8201 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g11209 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cni-unc-1 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold548.g3556 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00564.g12937 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_03159 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_022255 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g13275 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g10399 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_X0011800 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrX_pilon.g18376 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00240123 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00258451 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | WBGene00289000 | Trichuris muris | From_analysis | WormBase-Compara |
| | | FB:FBgn0030993 | Drosophila melanogaster | From_analysis | OMA |
| | | | | | Panther |
| | | FB:FBgn0250821 | Drosophila melanogaster | From_analysis | OrthoFinder |
| | | | | | Panther |
| | Paralog | WBGene00003166 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006063 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006064 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006065 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006066 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006067 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006068 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006761 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006061 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-1 encodes one of ten C. elegans stomatin-like proteins (SLPs) homologous to human erythrocyte surface protein band 7.2 (EPB72/Stomatin) (OMIM:133090; deficient in stomatocytosis); UNC-1 activity regulates electrical coupling between body wall muscles and is required in neurons for normal locomotion; unc-1 is also required for anesthetic sensitivity; an unc-1 promoter::DsRED2 fusion is expressed in body wall muscle, vulval muscle, anal-depressor muscle, stomatointestinal muscle, nearly all ventral cord motor neurons and the nerve ring; in neurons and body wall muscle, UNC-1 colocalizes with UNC-9, an innexin, at intercellular junctions; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and required for UNC-1 localization in the nerve ring. | Paper_evidence | WBPaper00000031 |
| | | | | | WBPaper00004649 |
| | | | | | WBPaper00030879 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 18 Jul 2008 00:00:00 |
| | | Automated_description | Enables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | K03E6.5a |
| | | K03E6.5b |
| | Corresponding_CDS_history | K03E6.5:wp188 |
| | Corresponding_transcript | K03E6.5a.1 |
| | | K03E6.5b.1 |
| | Other_sequence (59) |
| | Associated_feature | WBsf670099 |
| | | WBsf1003931 |
| | | WBsf1003932 |
| | | WBsf1022206 |
| | | WBsf1022207 |
| | | WBsf1022208 |
| | | WBsf236994 |
| | | WBsf236995 |
| | | WBsf236996 |
| Experimental_info | RNAi_result | WBRNAi00103042 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049837 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr527 |
| | | Expr887 |
| | | Expr3407 |
| | | Expr4819 |
| | | Expr1022667 |
| | | Expr1032816 |
| | | Expr1153550 |
| | | Expr2017854 |
| | | Expr2035990 |
| | Drives_construct | WBCnstr00012258 |
| | | WBCnstr00012259 |
| | | WBCnstr00012423 |
| | | WBCnstr00014590 |
| | | WBCnstr00019884 |
| | | WBCnstr00034181 |
| | Construct_product | WBCnstr00012423 |
| | | WBCnstr00023065 |
| | | WBCnstr00034181 |
| | | WBCnstr00042106 |
| | Antibody | WBAntibody00000361 |
| | | WBAntibody00000750 |
| | | WBAntibody00001262 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00046795:starvation_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051437:Cit-SPIONs_downregulated |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061274:microgravity_downregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061405:S.aureus_downregulated_starvation |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:65_0 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (129) |
| Map_info | Map | X | Position | -18.7759 | Error | 0.006952 |
| | Well_ordered |
| | Positive (2) |
| | Negative | Negative_clone | C55D6 |
| | | | T17A11 |
| | Mapping_data | 2_point (12) |
| | | Multi_point (38) |
| | | Pos_neg_data (46) |
| | Landmark_gene |
| Reference (109) |
| Method | Gene |