WormBase Tree Display for Gene: WBGene00003166
expand all nodes | collapse all nodes | view schema
| WBGene00003166 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mec-2 | Person_evidence | WBPerson95 | |||||
| Sequence_name | F14D12.4 | ||||||||
| Molecular_name (51) | |||||||||
| Other_name | CELE_F14D12.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mec-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Allele (374) | |||||||||
| Legacy_information | See also e75, e1084, e1514 | ||||||||
| [C.elegansII] u8amb : touch insensitive; lethargic. ES2. ME?. OA>50: e75 (recessive, ME3), u7cs, e1084 (probable null), e1514, e1608dm, u284sd, etc. Alleles vary in phenotype from weak recessive to strong dominant Mec; complex complementation. Cloned: encodes predicted 440 aa protein with central similarity to human stomatin (65% identity over 247 aa). mec-2:lacZ expressed in cell bodies and processes of touch cells, some other neurons.??? [Chalfie and Au 1989; Huang et al. 1995; TU] | |||||||||
| Strain | WBStrain00002820 | ||||||||
| WBStrain00037747 | |||||||||
| WBStrain00004463 | |||||||||
| WBStrain00004092 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00006761 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006068 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006065 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006741 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006064 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006063 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006067 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006066 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006061 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | The mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall. | Paper_evidence | WBPaper00005127 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1184 | Homo sapiens | Paper_evidence | WBPaper00044961 | ||||
| Accession_evidence | OMIM | 600995 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Sep 2018 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000328 | ||||||||
| Molecular_info | Corresponding_CDS (17) | ||||||||
| Corresponding_transcript (17) | |||||||||
| Other_sequence (86) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027647 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00013263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044585 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (18) | |||||||||
| Drives_construct | WBCnstr00003347 | ||||||||
| WBCnstr00004794 | |||||||||
| WBCnstr00010333 | |||||||||
| WBCnstr00011303 | |||||||||
| WBCnstr00011304 | |||||||||
| WBCnstr00036204 | |||||||||
| WBCnstr00042668 | |||||||||
| WBCnstr00042669 | |||||||||
| Construct_product | WBCnstr00010333 | ||||||||
| WBCnstr00011303 | |||||||||
| WBCnstr00036204 | |||||||||
| Antibody | WBAntibody00000792 | ||||||||
| WBAntibody00000793 | |||||||||
| WBAntibody00001354 | |||||||||
| WBAntibody00001686 | |||||||||
| WBAntibody00002696 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction (81) | |||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| Map_info | Map | X | Position | -4.70552 | Error | 0.075755 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F14D12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| W05G12 | Remark | Alternative clone not in the golden path of clones. | |||||||
| Negative | Outside_rearr | mcDf2 | |||||||
| Mapping_data | Multi_point (11) | ||||||||
| Pos_neg_data | 940 | ||||||||
| 1832 | |||||||||
| 3193 | |||||||||
| 500 | |||||||||
| 10696 | |||||||||
| Reference (113) | |||||||||
| Remark | Updated positive clone to correspond to the sequenced clone instead of just W05G12 | ||||||||
| Method | Gene |
