WormBase Tree Display for Gene: WBGene00001795

WBGene00001795 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C05C12
  Identity: Version: 1
    Name: CGC_name: gtl-1 Person_evidence: WBPerson51
      Sequence_name: C05C12.3
      Molecular_name: C05C12.3
        C05C12.3.1
        CE33754
      Other_name: tag-33 CGC_data_submission
        CELE_C05C12.3 Accession_evidence: NDB BX284604
      Public_name: gtl-1
    DB_info: Database: AceView gene 4M14
        WormQTL gene WBGene00001795
        WormFlux gene WBGene00001795
        NDB locus_tag CELE_C05C12.3
        Panther gene CAEEL|WormBase=WBGene00001795|UniProtKB=G5ECM4
          family PTHR13800
        NCBI gene 178031
        RefSeq protein NM_069710.6
        TrEMBL UniProtAcc G5ECM4
        UniProt_GCRP UniProtAcc G5ECM4
        OMIM gene 603576
            605692
            608961
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gtl
    Allele: WBVar02058948
      WBVar01500079
      WBVar01498996
      WBVar01609470
      WBVar01499925
      WBVar02134673
      WBVar01857929
      WBVar01499585
      WBVar00249398
      WBVar01499586
      WBVar00091672
      WBVar01966972
      WBVar01966973
      WBVar01818854
      WBVar00435563
      WBVar00435564
      WBVar00435565
      WBVar00435566
      WBVar00435567
      WBVar00435568
      WBVar00435569
      WBVar00435570
      WBVar00191968
      WBVar00191969
      WBVar00435571
      WBVar00435572
      WBVar00191970
      WBVar00435573
      WBVar00191971
      WBVar00435574
      WBVar00191972
      WBVar00435575
      WBVar00191973
      WBVar00435576
      WBVar00435577
      WBVar00435578
      WBVar00435579
      WBVar00435580
      WBVar00435581
      WBVar00435582
      WBVar00435583
      WBVar00435584
      WBVar00296456
      WBVar00296457
      WBVar00296458
      WBVar00942122
      WBVar02037166
      WBVar00942123
      WBVar00942124
      WBVar00942125
      WBVar00942126
      WBVar00942127
      WBVar00942128
      WBVar00942129
      WBVar00942130
      WBVar00942131
      WBVar01688137
      WBVar00942132
      WBVar00942133
      WBVar01688138
      WBVar00942134
      WBVar00942135
      WBVar00942136
      WBVar00942137
      WBVar00249271
      WBVar00942138
      WBVar00942139
      WBVar00942140
      WBVar00942141
      WBVar00942142
      WBVar00942143
      WBVar00942144
      WBVar00942145
      WBVar00942146
      WBVar00942147
      WBVar00942148
      WBVar00942149
      WBVar00942150
      WBVar00942151
      WBVar00942152
      WBVar00942153
      WBVar00942154
      WBVar01795540
      WBVar00942155
      WBVar00266428
      WBVar00942156
      WBVar00942157
      WBVar00942158
      WBVar01482376
      WBVar00942159
      WBVar00942160
      WBVar00942161
      WBVar00942162
      WBVar00942163
      WBVar00942164
      WBVar00942165
      WBVar00942166
      WBVar00942167
      WBVar00942168
      WBVar00942169
      WBVar00942170
      WBVar00252446
      WBVar00942171
      WBVar00942172
      WBVar00942173
      WBVar00942174
      WBVar01454187
      WBVar00942175
      WBVar00942176
      WBVar00942177
      WBVar02068734
      WBVar00942178
      WBVar01500245
      WBVar00942179
      WBVar00942180
      WBVar01846962
      WBVar00942181
      WBVar00942182
    Strain: WBStrain00003262
      WBStrain00035612
    RNASeq_FPKM (74)
    GO_annotation: 00012064
      00012065
      00012066
      00012067
      00012068
      00012069
    Ortholog (46)
    Paralog: WBGene00001651 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001796 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000425 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004149 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008731 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020972 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021404 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021408 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine. Paper_evidence: WBPaper00005092
            WBPaper00011328
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110867 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7146)
      DOID:0050534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7146)
      DOID:0111246 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17994)
      DOID:83 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17992)
  Molecular_info: Corresponding_CDS: C05C12.3
    Corresponding_CDS_history: C05C12.3:wp99
    Corresponding_transcript: C05C12.3.1
    Other_sequence: FK807706.1
      MHC01321_1
      MH01590
      Dviv_isotig25122
      FM207828.1
    Associated_feature: WBsf668304
      WBsf1018190
      WBsf230849
  Experimental_info: RNAi_result: WBRNAi00010181 Inferred_automatically: RNAi_primary
      WBRNAi00039701 Inferred_automatically: RNAi_primary
      WBRNAi00001394 Inferred_automatically: RNAi_primary
      WBRNAi00001519 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1622
      Expr3713
      Expr5160
      Expr8230
      Expr8232
      Expr1017897
      Expr1031057
      Expr1143801
      Expr2012342
      Expr2030579
    Drives_construct: WBCnstr00003737
      WBCnstr00007204
      WBCnstr00007207
      WBCnstr00007208
      WBCnstr00007209
      WBCnstr00011622
      WBCnstr00013197
      WBCnstr00021190
      WBCnstr00036678
    Construct_product: WBCnstr00011622
      WBCnstr00013197
      WBCnstr00036678
    Microarray_results (18)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_7
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055364:uaf-1(n4588)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:mdt-15(mg584)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061285:wounding_24h_upregulated
      WBPaper00061340:AVJ
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:RID
      WBPaper00061340:RID_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:gtl-1-hum-8_16432
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036286:Pattern_C
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037147:heatshock_downregulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
    Interaction (18)
  Map_info: Map: IV Position: 4.92955 Error: 0.001473
    Positive: Positive_clone: C05C12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4386
        4526
    Pseudo_map_position
  Reference (29)
  Remark: Sequence connection from Kwan CSM, Ragnauth CD and Baylis HA [021008 ck1]
    Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene