grl-13 encodes a hedgehog-like protein, with an N-terminal signalsequence, a central low-complexity region, and a C-terminal Ground-like(Grl) domain; GRL-13 is expressed in larval arcade cells; the Grl domainis predicted to form a cysteine-crosslinked protein involved inintercellular signalling, and it has subtle similarity to the N-terminalHedge domain of HEDGEHOG proteins.
Enriched in AVA; I5 neuron; RIAL; RIAR; and dopaminergic neurons based on tiling array and single-cell RNA-seq studies. Is affected by several genes including clk-1; sek-1; and pgl-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including methylmercuric chloride; Tunicamycin; and Rifampin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: Ground-like domain.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.