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WormBase Tree Display for Gene: WBGene00003997

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Name Class

WBGene00003997SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namepgp-3Person_evidenceWBPerson490
Sequence_nameZK455.7
Molecular_nameZK455.7
ZK455.7.1
CE03818
Other_namecepgpCAccession_evidenceEMBLX65055
CELE_ZK455.7Accession_evidenceNDBBX284606
Public_namepgp-3
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (77)
Legacy_information[C.elegansII] pk18 : deletion derived from pk30tci, increased sensitivity to colchicine and to chloroquine; gross phenotype WT. Cloned: encodes 1254 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcripts present throughout development; pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-3 detected in apical membranes of gut and of excretory cell. [Broeks et al. 1995; NL]
StrainWBStrain00028887
WBStrain00028888
WBStrain00028891
WBStrain00033025
WBStrain00037266
WBStrain00004731
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (71)
ParalogWBGene00001811Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001812Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001813Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001814Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001815Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001816Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001817Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001818Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001819Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003995Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003998Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00004003Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004002Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004001Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003999Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004000Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004004Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004006Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004007Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004008Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004005Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00022281Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003996Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionpgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells.Paper_evidenceWBPaper00002180
WBPaper00003366
WBPaper00003925
WBPaper00004651
WBPaper00005654
Curator_confirmedWBPerson1843
Date_last_updated03 Apr 2014 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Expressed in excretory canal; excretory cell; intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (41)
Molecular_infoCorresponding_CDSZK455.7
Corresponding_transcriptZK455.7.1
Other_sequence (21)
Associated_featureWBsf1006975
Experimental_infoRNAi_resultWBRNAi00059437Inferred_automaticallyRNAi_primary
WBRNAi00022018Inferred_automaticallyRNAi_primary
WBRNAi00014821Inferred_automaticallyRNAi_primary
WBRNAi00001488Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_constructWBCnstr00002142
WBCnstr00010331
WBCnstr00011338
WBCnstr00011339
WBCnstr00012125
WBCnstr00012126
WBCnstr00012634
WBCnstr00015310
WBCnstr00035753
Construct_productWBCnstr00012634
WBCnstr00014565
WBCnstr00014566
WBCnstr00035753
AntibodyWBAntibody00000095
Microarray_results (17)
Expression_clusterWBPaper00005700:transmembrane_protein
WBPaper00031040:Cluster_3
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:excretory-cell_larva_enriched
WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00046415:lithium_downregulated
WBPaper00046499:AMPK_regulated
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_upregulated
WBPaper00049377:MWCNT_downregulated
WBPaper00049484:elt-2(RNAi)_downregulated_L1
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00049954:BPA_upregulated
WBPaper00050121:mir-60(n4947)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050163:let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00051021:4-bromodiphenyl-ether_upregulated
WBPaper00051039:intestine_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053814:25C_downregulated_OP50
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057143:ztf-11(RNAi)_upregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
WBPaper00059421:daf-1(m40)_upregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
WBPaper00059604:fluvastatin_downregulated_N2
WBPaper00059987:Wounding_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060399:CoCl2_6hr_upregulated_N2
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060445:ikb-1(nr2027)_upregulated_L1
WBPaper00060661:sensory-neuron_depleted
WBPaper00061007:HB101_upregulated
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061340:AVA
WBPaper00061340:Excretory_cell
WBPaper00061341:28C_24h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:gst-26-pho-1_10767
WBPaper00061590:CGP37157_upregulated
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00061902:CAMT-1_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_N2_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064716:paraquat_downregulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064789:Day6_vs_Day1_upregulated_neuron
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064789:Day12_vs_Day1_upregulated_neuron
WBPaper00064871:PA14_upregulated_AWA
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:79_1
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4489_group_8
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00029437:dcr-1_upregulated
WBPaper00029437:rde-4_upregulated
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00032948:FedUp
WBPaper00034757:up_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036286:Pattern_I
WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
WBPaper00037113:Diazinon_16C_regulated
WBPaper00037695:LD_DD_6-day
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00039866:ClassComp_daf-19_downregulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_aging
WBPaper00040876:mir-35_downregulated
WBPaper00040963:Q200_up
WBPaper00040963:TA300_up
WBPaper00041211:RPW-24_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
WBPaper00055899:nitroguanidine_regulated
[cgc6390]:Cluster_C
Interaction (34)
Map_infoMapXPosition3.16596Error0.03869
PositivePositive_clonePB#CPG4
ZK455Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (46)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene