WormBase Tree Display for Gene: WBGene00003999
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| WBGene00003999 | SMap | S_parent | Sequence | C05A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-5 | Person_evidence | WBPerson490 | |||||
| Sequence_name | C05A9.1 | ||||||||
| Molecular_name | C05A9.1a | ||||||||
| C05A9.1a.1 | |||||||||
| CE43003 | |||||||||
| C05A9.1b | |||||||||
| CE43182 | |||||||||
| C05A9.1b.1 | |||||||||
| Other_name | CELE_C05A9.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pgp-5 | ||||||||
| DB_info | Database | AceView | gene | XL474 | |||||
| WormQTL | gene | WBGene00003999 | |||||||
| WormFlux | gene | WBGene00003999 | |||||||
| NDB | locus_tag | CELE_C05A9.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003999|UniProtKB=Q17645 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 181276 | |||||||
| RefSeq | protein | NM_001270188.3 | |||||||
| NM_001270187.3 | |||||||||
| TrEMBL | UniProtAcc | B6VQ78 | |||||||
| Q17645 | |||||||||
| UniProt_GCRP | UniProtAcc | Q17645 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (76) | |||||||||
| Strain | WBStrain00031670 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; pgp-5 activity is required for defense response to both Gram-negative and Gram-positive bacteria as well as for the response to heavy metal ions, including cadmium, copper, and zinc; pgp-5 is expressed in the intestine as well as in the terminal bulb of the pharynx; basal pgp-5 intestinal expression is regulated by TIR-1, while increased expression in response to stressors is under the contol of the p38 MAPK pathway. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00031023 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to metal ion. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (39) | ||||||||
| Molecular_info | Corresponding_CDS | C05A9.1a | |||||||
| C05A9.1b | |||||||||
| Corresponding_CDS_history | C05A9.1:wp194 | ||||||||
| Corresponding_transcript | C05A9.1a.1 | ||||||||
| C05A9.1b.1 | |||||||||
| Other_sequence | ES741656.1 | ||||||||
| Name_isotig09110 | |||||||||
| JI225225.1 | |||||||||
| AF128532.1 | |||||||||
| Tcol_isotig19406 | |||||||||
| MC00124 | |||||||||
| HBC03410_1 | |||||||||
| Associated_feature | WBsf654366 | ||||||||
| WBsf670999 | |||||||||
| WBsf1006839 | |||||||||
| WBsf1006840 | |||||||||
| WBsf237901 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00007288 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00028469 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094617 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039681 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1654 | ||||||||
| Expr3335 | |||||||||
| Expr3336 | |||||||||
| Expr12159 | |||||||||
| Expr1013923 | |||||||||
| Expr1143777 | |||||||||
| Expr2014872 | |||||||||
| Expr2033107 | |||||||||
| Drives_construct | WBCnstr00000017 | ||||||||
| WBCnstr00002012 | |||||||||
| WBCnstr00011331 | |||||||||
| WBCnstr00011332 | |||||||||
| WBCnstr00035751 | |||||||||
| Construct_product | WBCnstr00035751 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (297) | |||||||||
| Interaction (119) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | X | Position | 2.56721 | Error | 0.00819 | |||
| Positive | Positive_clone | C05A9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4579 | |||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Sequence connection from [Sheps JA, Baillie DL] [040902 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
