WormBase Tree Display for Gene: WBGene00003999
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WBGene00003999 | SMap | S_parent | Sequence | C05A9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pgp | ||||||
Allele (76) | |||||||
Strain | WBStrain00031670 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Ortholog (45) | |||||||
Paralog (23) | |||||||
Structured_description | Concise_description | pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; pgp-5 activity is required for defense response to both Gram-negative and Gram-positive bacteria as well as for the response to heavy metal ions, including cadmium, copper, and zinc; pgp-5 is expressed in the intestine as well as in the terminal bulb of the pharynx; basal pgp-5 intestinal expression is regulated by TIR-1, while increased expression in response to stressors is under the contol of the p38 MAPK pathway. | Paper_evidence | WBPaper00004651 | |||
WBPaper00005654 | |||||||
WBPaper00031023 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 14 Apr 2014 00:00:00 | ||||||
Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to metal ion. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (39) | ||||||
Molecular_info | Corresponding_CDS | C05A9.1a | |||||
C05A9.1b | |||||||
Corresponding_CDS_history | C05A9.1:wp194 | ||||||
Corresponding_transcript | C05A9.1a.1 | ||||||
C05A9.1b.1 | |||||||
Other_sequence | ES741656.1 | ||||||
Name_isotig09110 | |||||||
JI225225.1 | |||||||
AF128532.1 | |||||||
Tcol_isotig19406 | |||||||
MC00124 | |||||||
HBC03410_1 | |||||||
Associated_feature | WBsf654366 | ||||||
WBsf670999 | |||||||
WBsf1006839 | |||||||
WBsf1006840 | |||||||
WBsf237901 | |||||||
Experimental_info | RNAi_result | WBRNAi00007288 | Inferred_automatically | RNAi_primary | |||
WBRNAi00028469 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00010165 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00094617 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00039681 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1654 | ||||||
Expr3335 | |||||||
Expr3336 | |||||||
Expr12159 | |||||||
Expr1013923 | |||||||
Expr1143777 | |||||||
Expr2014872 | |||||||
Expr2033107 | |||||||
Drives_construct | WBCnstr00000017 | ||||||
WBCnstr00002012 | |||||||
WBCnstr00011331 | |||||||
WBCnstr00011332 | |||||||
WBCnstr00035751 | |||||||
Construct_product | WBCnstr00035751 | ||||||
Microarray_results (24) | |||||||
Expression_cluster (297) | |||||||
Interaction (119) | |||||||
WBProcess | WBbiopr:00000008 | ||||||
WBbiopr:00000039 | |||||||
Map_info | Map | X | Position | 2.56721 | Error | 0.00819 | |
Positive | Positive_clone | C05A9 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4579 | |||||
Pseudo_map_position | |||||||
Reference (19) | |||||||
Remark | Sequence connection from [Sheps JA, Baillie DL] [040902 ck1] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |