WormBase Tree Display for Gene: WBGene00003999

WBGene00003999 SMap: S_parent: Sequence: C05A9
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: pgp
    Allele (76)
    Strain: WBStrain00031670
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog: WBGene00023572 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023573 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023575 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023577 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00026762 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00028069 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00033821 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034135 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034271 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037005 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037006 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037161 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037162 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037165 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00194936 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00194937 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00123152 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00058400 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00183843 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      CSP29.g15950 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP32.g2095 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP39.g2742 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g19911 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_02477.g17231 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_08021.g21243 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_11445.g23239 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g23375 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13815 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00044.g2331 Caenorhabditis sinica From_analysis: WormBase-Compara
      Pan_g3036 Panagrellus redivivus From_analysis: WormBase-Compara
      chrX_pilon.g19955 Caenorhabditis elegans From_analysis: WormBase-Compara
      SGD:S000001692 Saccharomyces cerevisiae From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      FB:FBgn0004512 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      FB:FBgn0010241 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      FB:FBgn0035695 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0004513 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-030131-6414 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-080204-52 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:40 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:45 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97568 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97569 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97570 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:3318 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:620248 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
    Paralog (23)
    Structured_description: Concise_description: pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; pgp-5 activity is required for defense response to both Gram-negative and Gram-positive bacteria as well as for the response to heavy metal ions, including cadmium, copper, and zinc; pgp-5 is expressed in the intestine as well as in the terminal bulb of the pharynx; basal pgp-5 intestinal expression is regulated by TIR-1, while increased expression in response to stressors is under the contol of the p38 MAPK pathway. Paper_evidence: WBPaper00004651
            WBPaper00005654
            WBPaper00031023
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Apr 2014 00:00:00
      Automated_description: Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to metal ion. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (39)
  Molecular_info: Corresponding_CDS: C05A9.1a
      C05A9.1b
    Corresponding_CDS_history: C05A9.1:wp194
    Corresponding_transcript: C05A9.1a.1
      C05A9.1b.1
    Other_sequence: ES741656.1
      Name_isotig09110
      JI225225.1
      AF128532.1
      Tcol_isotig19406
      MC00124
      HBC03410_1
    Associated_feature: WBsf654366
      WBsf670999
      WBsf1006839
      WBsf1006840
      WBsf237901
  Experimental_info: RNAi_result: WBRNAi00007288 Inferred_automatically: RNAi_primary
      WBRNAi00028469 Inferred_automatically: RNAi_primary
      WBRNAi00010165 Inferred_automatically: RNAi_primary
      WBRNAi00094617 Inferred_automatically: RNAi_primary
      WBRNAi00039681 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1654
      Expr3335
      Expr3336
      Expr12159
      Expr1013923
      Expr1143777
      Expr2014872
      Expr2033107
    Drives_construct: WBCnstr00000017
      WBCnstr00002012
      WBCnstr00011331
      WBCnstr00011332
      WBCnstr00035751
    Construct_product: WBCnstr00035751
    Microarray_results (24)
    Expression_cluster (297)
    Interaction (119)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: X Position: 2.56721 Error: 0.00819
    Positive: Positive_clone: C05A9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4579
    Pseudo_map_position
  Reference (19)
  Remark: Sequence connection from [Sheps JA, Baillie DL] [040902 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene