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WormBase Tree Display for Gene: WBGene00003999

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Name Class

WBGene00003999SMapS_parentSequenceC05A9
IdentityVersion1
NameCGC_namepgp-5Person_evidenceWBPerson490
Sequence_nameC05A9.1
Molecular_nameC05A9.1a
C05A9.1a.1
CE43003
C05A9.1b
CE43182
C05A9.1b.1
Other_nameCELE_C05A9.1Accession_evidenceNDBBX284606
Public_namepgp-5
DB_infoDatabaseAceViewgeneXL474
WormQTLgeneWBGene00003999
WormFluxgeneWBGene00003999
NDBlocus_tagCELE_C05A9.1
PanthergeneCAEEL|WormBase=WBGene00003999|UniProtKB=Q17645
familyPTHR24221
NCBIgene181276
RefSeqproteinNM_001270188.3
NM_001270187.3
TrEMBLUniProtAccB6VQ78
Q17645
UniProt_GCRPUniProtAccQ17645
OMIMgene171050
171060
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (76)
StrainWBStrain00031670
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (45)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins; pgp-5 activity is required for defense response to both Gram-negative and Gram-positive bacteria as well as for the response to heavy metal ions, including cadmium, copper, and zinc; pgp-5 is expressed in the intestine as well as in the terminal bulb of the pharynx; basal pgp-5 intestinal expression is regulated by TIR-1, while increased expression in response to stressors is under the contol of the p38 MAPK pathway.Paper_evidenceWBPaper00004651
WBPaper00005654
WBPaper00031023
Curator_confirmedWBPerson1843
Date_last_updated14 Apr 2014 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to metal ion. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (39)
Molecular_infoCorresponding_CDSC05A9.1a
C05A9.1b
Corresponding_CDS_historyC05A9.1:wp194
Corresponding_transcriptC05A9.1a.1
C05A9.1b.1
Other_sequenceES741656.1
Name_isotig09110
JI225225.1
AF128532.1
Tcol_isotig19406
MC00124
HBC03410_1
Associated_featureWBsf654366
WBsf670999
WBsf1006839
WBsf1006840
WBsf237901
Experimental_infoRNAi_resultWBRNAi00007288Inferred_automaticallyRNAi_primary
WBRNAi00028469Inferred_automaticallyRNAi_primary
WBRNAi00010165Inferred_automaticallyRNAi_primary
WBRNAi00094617Inferred_automaticallyRNAi_primary
WBRNAi00039681Inferred_automaticallyRNAi_primary
Expr_patternChronogram1654
Expr3335
Expr3336
Expr12159
Expr1013923
Expr1143777
Expr2014872
Expr2033107
Drives_constructWBCnstr00000017
WBCnstr00002012
WBCnstr00011331
WBCnstr00011332
WBCnstr00035751
Construct_productWBCnstr00035751
Microarray_results (24)
Expression_clusterWBPaper00031132:LiCl_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038421:egl-4(lf)_upregulated
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040285:H2S_12hr_downregulated
WBPaper00040285:H2S_24hr_downregulated
WBPaper00040560:hpl-2_L3_downregulated
WBPaper00040990:PA14_upregulated
WBPaper00041954:ethanol_upregulated
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00043945:MeHg_downregulated
WBPaper00044316:HgCl2_20uM_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044760:somatic_specific
WBPaper00045401:N.parisii_40h_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00046415:lithium_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046858:elt-2(RNAi)_upregulated
WBPaper00048611:MnCl2_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049134:hpk-1(pk1393)_upregulated
WBPaper00049217:DAF-16_downregulated
WBPaper00049290:rsks-1(sv31)_downregulated
WBPaper00049334:CE_intestine_enriched
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049377:MWCNT_downregulated
WBPaper00049498:npr-1(ur89)_regulated_5
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049905:Age_variant_expression
WBPaper00049942:HeatShock_downregulated_hsf-1(+)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050121:mir-60(n4947)_downregulated
WBPaper00050182:lmn-1(L535P)_upregulated
WBPaper00050193:cec-4(ok3124)_upregulated_L1
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050801:SET-4_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:intestine_expressed
WBPaper00051021:4-bromodiphenyl-ether_upregulated
WBPaper00051039:intestine_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053020:sid-3(ok973)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053402:his-3(RNAi)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053657:N2_M.humicola-infection_24hr
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053771:up_at_24h-NaCl
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00054410:set-9(rw5)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055941:atfs-1(et15)_downregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056039:efa-6(tm3124)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056167:Cry5B_downregulated
WBPaper00056167:ifo-1(kc2)_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_L4
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
WBPaper00056284:ints-4(RNAi)_upregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:spc-1(cas971)_downregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057196:raga-1(ok386)_upregulated)
WBPaper00057265:metaformin_upregulated_OP50
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058948:npr-8(ok1439)_downregulated_OP50
WBPaper00058948:PA14_downregulated
WBPaper00059175:hlh-17p-XBP-1_upregulated
WBPaper00059231:alh-6(lax105)_L4_downregulated
WBPaper00059253:sucrose_downregulated
WBPaper00059253:sucrose_stearic-acid_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
WBPaper00059537:ngn-1(ok2200)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060273:isp-1(qm150)_downregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:CoCl2_6hr_upregulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060445:ikb-1(nr2027)_upregulated_L1
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:hypoxia_upregulated
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060764:swsn-9(ok1354)_upregulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00060909:atfs-1(et18)_upregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061007:HB101_upregulated
WBPaper00061007:HB115_downregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061340:pm1_pm2
WBPaper00061341:28C_24h_upregulated
WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061527:C10C5.2-Y58A7A.3
WBPaper00061613:human-alpha-Synuclein(A53T)_downregulated
WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
WBPaper00061651:NSM_enriched
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062456:doxycycline_upregulated_CB4856_transcript
WBPaper00062456:doxycycline_upregulated_N2_transcript
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062520:qui-1(db104)_downregulated
WBPaper00062590:Aging_upregulated_intestine
WBPaper00062590:Aging_upregulated_neuron
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064130:Beta-Amyloid_8h_downregulated_mRNA
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064509:static-magnetic-field_upregulated
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00064532:pals-25(icb98)_upregulated
WBPaper00064632:daf-2(e1370)_downregulated_intestine
WBPaper00064716:paraquat_upregulated
WBPaper00064762:freezing-thaw_regulated
WBPaper00064871:PA14_upregulated_AWA
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065005:sams-3(RNAi)_upregulated
WBPaper00065005:sams-4(RNAi)_upregulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065086:N2_N.ferruginous_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
WBPaper00065331:100nM-ivermectin_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065841:11_0
WBPaper00065841:13_0
WBPaper00065841:31_0
WBPaper00065841:86_0
WBPaper00065841:116_0
WBPaper00065841:140_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066004:ceh-14(ch3)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025099:MA_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026629:L4_male_enriched
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026952:class_E
WBPaper00027111:eri-1(mg366)_upregulated
WBPaper00028789:PA14_vs_gacA_upregulated_4hr
WBPaper00028789:PA14_vs_gacA_upregulated_8hr
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00028789:PA14_vs_OP50_upregulated_8hr
WBPaper00028948:cep-1(gk138)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00034757:up_by_oxidative_stress
WBPaper00035227:bio-electrospray_regulated
WBPaper00035891:PA_induced_zip-2_dependent
WBPaper00035891:zip-2(RNAi)_downregulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_D
WBPaper00036383:ash-2_L3_regulated
WBPaper00038172:crh-1null_up_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038304:octr-1_regulated
WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00041207:CE_dauer_up
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041876:daf-10(m79)_downreglated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00044013:nasp-1_downregulated
WBPaper00044091:Bpseudomallei_induced_2h
WBPaper00044091:Bpseudomallei_induced_4h
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045263:ProLongevity-mtROS_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00047070:DAF-16-dependent_UV_response
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
WBPaper00055899:nitroguanidine_regulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:Cluster_B
Interaction (119)
WBProcessWBbiopr:00000008
WBbiopr:00000039
Map_infoMapXPosition2.56721Error0.00819
PositivePositive_cloneC05A9Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4579
Pseudo_map_position
Reference (19)
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene