WormBase Tree Display for Gene: WBGene00004000
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| WBGene00004000 | SMap | S_parent | Sequence | T21E8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-6 | Person_evidence | WBPerson490 | |||||
| Sequence_name | T21E8.1 | ||||||||
| Molecular_name | T21E8.1a | ||||||||
| T21E8.1a.1 | |||||||||
| CE40818 | |||||||||
| T21E8.1b | |||||||||
| CE40819 | |||||||||
| T21E8.1c | |||||||||
| CE46295 | |||||||||
| T21E8.1b.1 | |||||||||
| T21E8.1c.1 | |||||||||
| Other_name | CELE_T21E8.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pgp-6 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004000 | |||||
| WormFlux | gene | WBGene00004000 | |||||||
| NDB | locus_tag | CELE_T21E8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004000|UniProtKB=Q22656 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 181278 | |||||||
| RefSeq | protein | NM_001047822.7 | |||||||
| NM_001270189.3 | |||||||||
| NM_001047823.5 | |||||||||
| TrEMBL | UniProtAcc | Q22656 | |||||||
| G1K0X0 | |||||||||
| Q1ZXU6 | |||||||||
| UniProt_GCRP | UniProtAcc | Q22656 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| 603201 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (68) | |||||||||
| Strain | WBStrain00031754 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (58) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-6 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-6 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-6 activity via RNAi results in no obvious defects, the precise role of PGP-6 in C. elegans development and/or behavior is not yet known; pgp-6 promoter-gfp fusion proteins are expressed larvae and adults in the amphids, pharynx, intestine, and other unidentified cells in the head. | Paper_evidence | WBPaper00006421 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00024561 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Mar 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in plasma membrane. Expressed in amphid neurons and head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | T21E8.1a | |||||||
| T21E8.1b | |||||||||
| T21E8.1c | |||||||||
| Corresponding_CDS_history | T21E8.1a:wp173 | ||||||||
| T21E8.1b:wp173 | |||||||||
| Corresponding_transcript | T21E8.1a.1 | ||||||||
| T21E8.1b.1 | |||||||||
| T21E8.1c.1 | |||||||||
| Other_sequence | HCC00172_1 | ||||||||
| EX827636.1 | |||||||||
| DI00477 | |||||||||
| HC05919 | |||||||||
| HCC00086_1 | |||||||||
| DIC00160_1 | |||||||||
| JI216993.1 | |||||||||
| FC814140.1 | |||||||||
| FC814151.1 | |||||||||
| HM635771.1 | |||||||||
| Associated_feature | WBsf654367 | ||||||||
| WBsf718696 | |||||||||
| WBsf237903 | |||||||||
| WBsf237904 | |||||||||
| WBsf237905 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00053748 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00018983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053749 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2012 | ||||||||
| Expr3329 | |||||||||
| Expr3330 | |||||||||
| Expr6733 | |||||||||
| Expr1157296 | |||||||||
| Expr2014873 | |||||||||
| Expr2033108 | |||||||||
| Drives_construct | WBCnstr00002015 | ||||||||
| WBCnstr00004198 | |||||||||
| WBCnstr00011325 | |||||||||
| WBCnstr00011326 | |||||||||
| WBCnstr00035750 | |||||||||
| Construct_product | WBCnstr00011326 | ||||||||
| WBCnstr00035750 | |||||||||
| Microarray_results (11) | |||||||||
| Expression_cluster (271) | |||||||||
| Interaction (33) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | X | Position | 2.67006 | Error | 0.013339 | |||
| Positive | Positive_clone | T21E8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4566 | |||||||
| 4578 | |||||||||
| 4579 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Sequence connection from [Sheps JA, Baillie DL] [040902 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
