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WormBase Tree Display for Gene: WBGene00004000

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Name Class

WBGene00004000SMapS_parentSequenceT21E8
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (68)
StrainWBStrain00031754
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (58)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-6 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-6 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-6 activity via RNAi results in no obvious defects, the precise role of PGP-6 in C. elegans development and/or behavior is not yet known; pgp-6 promoter-gfp fusion proteins are expressed larvae and adults in the amphids, pharynx, intestine, and other unidentified cells in the head.Paper_evidenceWBPaper00006421
WBPaper00006525
WBPaper00024561
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated06 Mar 2006 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in plasma membrane. Expressed in amphid neurons and head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (41)
Molecular_infoCorresponding_CDST21E8.1a
T21E8.1b
T21E8.1c
Corresponding_CDS_historyT21E8.1a:wp173
T21E8.1b:wp173
Corresponding_transcriptT21E8.1a.1
T21E8.1b.1
T21E8.1c.1
Other_sequenceHCC00172_1
EX827636.1
DI00477
HC05919
HCC00086_1
DIC00160_1
JI216993.1
FC814140.1
FC814151.1
HM635771.1
Associated_featureWBsf654367
WBsf718696
WBsf237903
WBsf237904
WBsf237905
Experimental_infoRNAi_resultWBRNAi00053748Inferred_automaticallyRNAi_primary
WBRNAi00018983Inferred_automaticallyRNAi_primary
WBRNAi00018982Inferred_automaticallyRNAi_primary
WBRNAi00053749Inferred_automaticallyRNAi_primary
Expr_patternChronogram2012
Expr3329
Expr3330
Expr6733
Expr1157296
Expr2014873
Expr2033108
Drives_constructWBCnstr00002015
WBCnstr00004198
WBCnstr00011325
WBCnstr00011326
WBCnstr00035750
Construct_productWBCnstr00011326
WBCnstr00035750
Microarray_results (11)
Expression_cluster (271)
Interaction (33)
WBProcessWBbiopr:00000001
Map_infoMapXPosition2.67006Error0.013339
PositivePositive_cloneT21E8Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4566
4578
4579
Pseudo_map_position
Reference (16)
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene