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WormBase Tree Display for Gene: WBGene00004008

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Name Class

WBGene00004008SMapS_parentSequenceF22E10
IdentityVersion1
NameCGC_namepgp-14Person_evidenceWBPerson490
Sequence_nameF22E10.3
Molecular_nameF22E10.3
F22E10.3.1
CE03262
Other_nameCELE_F22E10.3Accession_evidenceNDBBX284606
Public_namepgp-14
DB_infoDatabaseAceViewgeneXN364
WormQTLgeneWBGene00004008
WormFluxgeneWBGene00004008
NDBlocus_tagCELE_F22E10.3
PanthergeneCAEEL|WormBase=WBGene00004008|UniProtKB=G5EG61
familyPTHR24221
NCBIgene181416
RefSeqproteinNM_077727.10
TrEMBLUniProtAccG5EG61
UniProt_GCRPUniProtAccG5EG61
OMIMgene171050
171060
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (62)
StrainWBStrain00001996
WBStrain00032692
RNASeq_FPKM (74)
GO_annotation (12)
Contained_in_operonCEOPX110
Ortholog (53)
Paralog (24)
Structured_descriptionConcise_descriptionpgp-14 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-14 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-14 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-14 in C. elegans development and/or behavior is not yet known; pgp-14 promoter-gfp fusion proteins are expressed in larvae and adults in the anterior pharynx.Paper_evidenceWBPaper00006421
WBPaper00006525
WBPaper00024561
Curator_confirmedWBPerson1843
WBPerson48
Date_last_updated07 Mar 2006 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_model (34)
Molecular_infoCorresponding_CDSF22E10.3
Corresponding_transcriptF22E10.3.1
Other_sequenceJI168113.1
JI235600.1
JI231282.1
JI164894.1
Acan_isotig21429
JI218053.1
CJC02657_1
ASC19568_1
JI241304.1
Associated_featureWBsf238081
WBsf238082
WBsf238083
Experimental_infoRNAi_resultWBRNAi00045324Inferred_automaticallyRNAi_primary
WBRNAi00000347Inferred_automaticallyRNAi_primary
WBRNAi00077361Inferred_automaticallyRNAi_primary
WBRNAi00013753Inferred_automaticallyRNAi_primary
Expr_patternExpr3326
Expr3327
Expr4618
Expr5828
Expr1031917
Expr1149248
Expr2014867
Expr2033102
Drives_constructWBCnstr00002780
WBCnstr00011322
WBCnstr00011323
WBCnstr00012122
WBCnstr00035743
Construct_productWBCnstr00035743
Microarray_results (16)
Expression_cluster (209)
Interaction (33)
Map_infoMapXPosition8.21375Error0.008856
PositivePositive_cloneF22E10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (11)
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene