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WormBase Tree Display for Gene: WBGene00000170

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Name Class

WBGene00000170EvidencePerson_evidenceWBPerson548
SMapS_parentSequenceC01G6
IdentityVersion1
NameCGC_nameaqp-2Person_evidenceWBPerson300
Sequence_nameC01G6.1
Molecular_nameC01G6.1a
C01G6.1a.1
CE00863
C01G6.1b
CE19664
C01G6.1b.1
C01G6.1b.2
Other_nameCELE_C01G6.1Accession_evidenceNDBBX284602
Public_nameaqp-2
DB_infoDatabaseAceViewgene2J550
WormQTLgeneWBGene00000170
WormFluxgeneWBGene00000170
NDBlocus_tagCELE_C01G6.1
PanthergeneCAEEL|WormBase=WBGene00000170|UniProtKB=Q17571
familyPTHR43829
NCBIgene174467
RefSeqproteinNM_001393149.1
NM_001381560.2
TREEFAMTREEFAM_IDTF313173
TrEMBLUniProtAccQ17571
Q7JMQ6
UniProt_GCRPUniProtAccQ17571
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaqp
AlleleWBVar02149947
WBVar01696109
WBVar01499702
WBVar01498435
WBVar01604429
WBVar01499017
WBVar00105277
WBVar00755177
WBVar00755178
WBVar00755179
WBVar00755180
WBVar00755181
WBVar00755182
WBVar00755183
WBVar00755184
WBVar00755185
WBVar00755186
WBVar00174543
WBVar00755187
WBVar00755188
WBVar02018106
WBVar00755189
WBVar00755190
WBVar00373746
WBVar00755191
WBVar00373747
WBVar00373748
WBVar00755192
WBVar00755193
WBVar00373749
WBVar01405462
WBVar00755194
WBVar00373750
WBVar00373751
WBVar00755195
WBVar00755196
WBVar00093334
WBVar00373752
WBVar00755197
WBVar00373753
WBVar00755198
WBVar00373754
WBVar00373755
WBVar00755199
WBVar00755200
WBVar00755201
WBVar00755202
WBVar00755203
WBVar01243097
WBVar01243099
WBVar01309266
WBVar01498940
StrainWBStrain00032407
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (47)
ParalogWBGene00000169Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000176Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000175Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013272Caenorhabditis elegansFrom_analysisPanther
WBGene00000171Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000172Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000173Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000174Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionaqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress.Paper_evidenceWBPaper00003343
WBPaper00013089
WBPaper00025051
WBPaper00027009
WBPaper00027351
WBPaper00029039
WBPaper00030907
Curator_confirmedWBPerson1843
Date_last_updated12 Aug 2007 00:00:00
Automated_descriptionEnables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4724Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:636)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:0060180Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:11981Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
Molecular_infoCorresponding_CDSC01G6.1a
C01G6.1b
Corresponding_transcriptC01G6.1a.1
C01G6.1b.1
C01G6.1b.2
Other_sequence (55)
Associated_feature (22)
Experimental_infoRNAi_result (13)
Expr_patternExpr4772
Expr1017046
Expr1030096
Expr1143468
Expr2009380
Expr2027616
Drives_constructWBCnstr00012232
WBCnstr00037690
Construct_productWBCnstr00037690
Microarray_results (37)
Expression_clusterWBPaper00032031:DConiospora_downregulated_cDNA_12h
WBPaper00032031:DConiospora_downregulated_cDNA_24h
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00032528:L3_enriched
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L3
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046795:starvation_upregulated
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00046805:csr-1(RNAi)_downregulated_Set2
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050094:mes-6(bn66)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051388:Glucose-diet_upregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:female_vs_male_downregulated
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00054192:cold-shock_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00055981:fog-2(q71)_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059763:neuron_expressed
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061040:FW1256_downregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Body_wall_muscle
WBPaper00061340:BWM_anterior
WBPaper00061340:CEPsh
WBPaper00061340:CEPso
WBPaper00061340:Excretory_cell
WBPaper00061340:Excretory_duct_and_pore
WBPaper00061340:Excretory_gland
WBPaper00061340:F_U
WBPaper00061340:Glia
WBPaper00061340:GLR
WBPaper00061340:hyp3
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061340:ILso
WBPaper00061340:Intestinal_and_rectal_muscle
WBPaper00061340:K_Kprime
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061466:nath-10(icb99)_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:hda-1(ne4747)_upregulated
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061479:hrde-1(tm1200)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:unc-44_403-H24G06.1_2859
WBPaper00061651:AS_enriched
WBPaper00061651:AVG_enriched
WBPaper00061651:CEPsh_enriched
WBPaper00061651:DA9_enriched
WBPaper00061651:DA_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:IL2_LR_enriched
WBPaper00061651:M3_enriched
WBPaper00061651:PHB_enriched
WBPaper00061651:PHso_enriched
WBPaper00061651:PVD_enriched
WBPaper00061651:PVT_enriched
WBPaper00061651:PVW_enriched
WBPaper00061651:XXX_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:etr-1(lq61)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00062684:pathogen_upregulated_N2
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064201:SNA-3_interacting
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064871:hypoxia_downregulated_F3
WBPaper00065029:cadmium_upregulated
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:25C_vs_15C_upregulated_AFD
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065392:Lb.gasseri_downregulated
WBPaper00065392:P.pentosaceus_downregulated
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
WBPaper00065841:14_0
WBPaper00065841:38_0
WBPaper00065841:38_1
WBPaper00065841:40_0
WBPaper00065841:64_0
WBPaper00065841:131_0
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066093:E.coli-purE_downregulated
WBPaper00066232:ash-2(RNAi)_upregulated_WT
cgc4386_cluster_6_2
WBPaper00025032:cluster_24
WBPaper00025032:cluster_60
WBPaper00025032:PAL-1_target_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00027111:rrf-1(pk1417)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00031003:hlh_1_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00033101:spr-5_regulated
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-7_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035873:osm-11_regulated
WBPaper00038060:SUMO-1_downregulated
WBPaper00038304:octr-1_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_2.0mM_Down
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042236:flcn-1(ok975)_upregulated
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00046639:tyrosol_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00050767:Octopamine_induced
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_5
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_SE
[cgc5767]:expression_class_SE_pi(53_min)
Interaction (19)
Map_infoMapIIPosition1.09711Error0.000462
PositivePositive_cloneC01G6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (13)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene