WormBase Tree Display for Gene: WBGene00000171

WBGene00000171 Evidence: Person_evidence: WBPerson548
  SMap: S_parent: Sequence: Y69E1A
  Identity: Version: 1
    Name: CGC_name: aqp-3 Person_evidence: WBPerson300
      Sequence_name: Y69E1A.7
      Molecular_name: Y69E1A.7a
        Y69E1A.7a.1
        CE22814
        Y69E1A.7b
        CE49844
        Y69E1A.7c
        CE51447
        Y69E1A.7b.1
        Y69E1A.7c.1
      Other_name: CELE_Y69E1A.7 Accession_evidence: NDB BX284604
      Public_name: aqp-3
    DB_info: Database: AceView gene 4L724
        WormQTL gene WBGene00000171
        WormFlux gene WBGene00000171
        NDB locus_tag CELE_Y69E1A.7
        Panther gene CAEEL|WormBase=WBGene00000171|UniProtKB=Q9XW36
          family PTHR43829
        NCBI gene 190553
        RefSeq protein NM_001306967.3
            NM_069643.2
            NM_001322776.4
        TrEMBL UniProtAcc A0A131MBS2
            A0A061ADS9
            Q9XW36
        UniProt_GCRP UniProtAcc Q9XW36
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aqp
    Allele (74)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (51)
    Paralog: WBGene00000169 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000170 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000176 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000175 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013272 Caenorhabditis elegans From_analysis: Panther
      WBGene00000172 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000173 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000174 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: aqp-3 encodes an aquaglyceroporin whose expression in Xenopus oocytes increases water or glycerol permeability five- to seven-fold; loss of AQP-3 activity via mutation or RNAi results in no obvious defects; however, AQP-3, in conjunction with AQP-2, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress; AQP-3 is expressed in the intestine, excretory cell, seminal vesicle, and vas deferens. Paper_evidence: WBPaper00029039
            WBPaper00030907
          Curator_confirmed: WBPerson567
          Date_last_updated: 12 Aug 2007 00:00:00
      Automated_description: Enables water channel activity. Involved in glycerol transmembrane transport and water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; intestine; and vas deferens. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:636)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:0060180 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
  Molecular_info: Corresponding_CDS: Y69E1A.7a
      Y69E1A.7b
      Y69E1A.7c
    Corresponding_transcript: Y69E1A.7a.1
      Y69E1A.7b.1
      Y69E1A.7c.1
    Other_sequence (63)
    Associated_feature: WBsf997736
  Experimental_info: RNAi_result: WBRNAi00101341 Inferred_automatically: RNAi_primary
      WBRNAi00101338 Inferred_automatically: RNAi_primary
      WBRNAi00058066 Inferred_automatically: RNAi_primary
      WBRNAi00021326 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4773
      Expr1015507
      Expr1161482
    Drives_construct: WBCnstr00012233
      WBCnstr00037689
    Construct_product: WBCnstr00037689
    Microarray_results (18)
    Expression_cluster (78)
    Interaction (67)
  Map_info: Map: IV Position: 4.76429 Error: 0.003171
    Positive: Positive_clone: Y69E1A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5507
        5510
        4263
    Pseudo_map_position
  Reference: WBPaper00029039
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene