WormBase Tree Display for Gene: WBGene00000169

WBGene00000169 Evidence: Person_evidence: WBPerson548
  SMap: S_parent: Sequence: F32A5
  Identity: Version: 2
    Name: CGC_name: aqp-1 Person_evidence: WBPerson300
      Sequence_name: F32A5.5
      Molecular_name: F32A5.5a
        F32A5.5a.1
        CE29304
        F32A5.5b
        CE01275
        F32A5.5b.1
      Other_name: dod-4
        CELE_F32A5.5 Accession_evidence: NDB BX284602
      Public_name: aqp-1
    DB_info: Database: AceView gene 2H526
        WormQTL gene WBGene00000169
        WormFlux gene WBGene00000169
        NDB locus_tag CELE_F32A5.5
        Panther gene CAEEL|WormBase=WBGene00000169|UniProtKB=Q19949
          family PTHR43829
        NCBI gene 174190
        RefSeq protein NM_063109.6
            NM_001381493.2
        TREEFAM TREEFAM_ID TF313173
        TrEMBL UniProtAcc Q19949
            Q8IG23
        UniProt_GCRP UniProtAcc Q19949
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 25 Aug 2004 11:36:28 WBPerson1971 Name_change: Other_name: dod-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aqp
    Allele (34)
    Strain: WBStrain00004916
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (40)
    Paralog: WBGene00000171 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000176 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000175 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013272 Caenorhabditis elegans From_analysis: Panther
      WBGene00000170 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000172 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000173 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000174 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa. Paper_evidence: WBPaper00005976
            WBPaper00028482
            WBPaper00029039
            WBPaper00030907
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 12 Aug 2007 00:00:00
      Automated_description: Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:636)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:0060180 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
  Molecular_info: Corresponding_CDS: F32A5.5a
      F32A5.5b
    Corresponding_transcript: F32A5.5a.1
      F32A5.5b.1
    Other_sequence (15)
    Associated_feature: WBsf019168
      WBsf650216
      WBsf650217
      WBsf223316
  Experimental_info: RNAi_result: WBRNAi00097044 Inferred_automatically: RNAi_primary
      WBRNAi00094564 Inferred_automatically: RNAi_primary
      WBRNAi00014195 Inferred_automatically: RNAi_primary
      WBRNAi00063161 Inferred_automatically: RNAi_primary
      WBRNAi00031645 Inferred_automatically: RNAi_primary
      WBRNAi00046077 Inferred_automatically: RNAi_primary
      WBRNAi00097048 Inferred_automatically: RNAi_primary
      WBRNAi00094561 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4771
      Expr1017935
      Expr1149967
      Expr2009379
      Expr2027615
    Drives_construct: WBCnstr00012231
      WBCnstr00017137
      WBCnstr00037691
    Construct_product: WBCnstr00012231
      WBCnstr00017137
      WBCnstr00037691
    Microarray_results (25)
    Expression_cluster (279)
    Interaction (92)
  Map_info: Map: II Position: 0.499703 Error: 3.1e-05
    Positive: Positive_clone: F32A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene