WormBase Tree Display for Gene: WBGene00000169
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| WBGene00000169 | Evidence | Person_evidence | WBPerson548 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F32A5 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | aqp-1 | Person_evidence | WBPerson300 | |||||
| Sequence_name | F32A5.5 | ||||||||
| Molecular_name | F32A5.5a | ||||||||
| F32A5.5a.1 | |||||||||
| CE29304 | |||||||||
| F32A5.5b | |||||||||
| CE01275 | |||||||||
| F32A5.5b.1 | |||||||||
| Other_name | dod-4 | ||||||||
| CELE_F32A5.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | aqp-1 | ||||||||
| DB_info | Database | AceView | gene | 2H526 | |||||
| WormQTL | gene | WBGene00000169 | |||||||
| WormFlux | gene | WBGene00000169 | |||||||
| NDB | locus_tag | CELE_F32A5.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000169|UniProtKB=Q19949 | |||||||
| family | PTHR43829 | ||||||||
| NCBI | gene | 174190 | |||||||
| RefSeq | protein | NM_063109.6 | |||||||
| NM_001381493.2 | |||||||||
| TREEFAM | TREEFAM_ID | TF313173 | |||||||
| TrEMBL | UniProtAcc | Q19949 | |||||||
| Q8IG23 | |||||||||
| UniProt_GCRP | UniProtAcc | Q19949 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 25 Aug 2004 11:36:28 | WBPerson1971 | Name_change | Other_name | dod-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aqp | ||||||||
| Allele | WBVar00742918 | ||||||||
| WBVar00742919 | |||||||||
| WBVar00742920 | |||||||||
| WBVar01499702 | |||||||||
| WBVar00742921 | |||||||||
| WBVar00742922 | |||||||||
| WBVar00742923 | |||||||||
| WBVar00742924 | |||||||||
| WBVar00742925 | |||||||||
| WBVar00742926 | |||||||||
| WBVar00742927 | |||||||||
| WBVar00742928 | |||||||||
| WBVar00369790 | |||||||||
| WBVar00742929 | |||||||||
| WBVar00369791 | |||||||||
| WBVar00742930 | |||||||||
| WBVar00369792 | |||||||||
| WBVar00742931 | |||||||||
| WBVar00369793 | |||||||||
| WBVar00742932 | |||||||||
| WBVar00225615 | |||||||||
| WBVar00742933 | |||||||||
| WBVar00742934 | |||||||||
| WBVar00173204 | |||||||||
| WBVar00742935 | |||||||||
| WBVar01498435 | |||||||||
| WBVar02130211 | |||||||||
| WBVar00251211 | |||||||||
| WBVar00598432 | |||||||||
| WBVar00104486 | |||||||||
| WBVar00104487 | |||||||||
| WBVar01498940 | |||||||||
| WBVar00742916 | |||||||||
| WBVar00742917 | |||||||||
| Strain | WBStrain00004916 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00000171 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000176 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00000170 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa. | Paper_evidence | WBPaper00005976 | |||||
| WBPaper00028482 | |||||||||
| WBPaper00029039 | |||||||||
| WBPaper00030907 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Aug 2007 00:00:00 | ||||||||
| Automated_description | Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) | ||||
| DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
| Molecular_info | Corresponding_CDS | F32A5.5a | |||||||
| F32A5.5b | |||||||||
| Corresponding_transcript | F32A5.5a.1 | ||||||||
| F32A5.5b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf019168 | ||||||||
| WBsf650216 | |||||||||
| WBsf650217 | |||||||||
| WBsf223316 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097044 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00094564 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014195 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063161 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031645 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046077 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097048 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094561 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4771 | ||||||||
| Expr1017935 | |||||||||
| Expr1149967 | |||||||||
| Expr2009379 | |||||||||
| Expr2027615 | |||||||||
| Drives_construct | WBCnstr00012231 | ||||||||
| WBCnstr00017137 | |||||||||
| WBCnstr00037691 | |||||||||
| Construct_product | WBCnstr00012231 | ||||||||
| WBCnstr00017137 | |||||||||
| WBCnstr00037691 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (279) | |||||||||
| Interaction (92) | |||||||||
| Map_info | Map | II | Position | 0.499703 | Error | 3.1e-05 | |||
| Positive | Positive_clone | F32A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
