WormBase Tree Display for Gene: WBGene00000169

WBGene00000169 Evidence: Person_evidence: WBPerson548
  SMap: S_parent: Sequence: F32A5
  Identity: Version: 2
    Name: CGC_name: aqp-1 Person_evidence: WBPerson300
      Sequence_name: F32A5.5
      Molecular_name: F32A5.5a
        F32A5.5a.1
        CE29304
        F32A5.5b
        CE01275
        F32A5.5b.1
      Other_name: dod-4
        CELE_F32A5.5 Accession_evidence: NDB BX284602
      Public_name: aqp-1
    DB_info: Database: AceView gene 2H526
        WormQTL gene WBGene00000169
        WormFlux gene WBGene00000169
        NDB locus_tag CELE_F32A5.5
        Panther gene CAEEL|WormBase=WBGene00000169|UniProtKB=Q19949
          family PTHR43829
        NCBI gene 174190
        RefSeq protein NM_063109.6
            NM_001381493.2
        TREEFAM TREEFAM_ID TF313173
        TrEMBL UniProtAcc Q19949
            Q8IG23
        UniProt_GCRP UniProtAcc Q19949
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 25 Aug 2004 11:36:28 WBPerson1971 Name_change: Other_name: dod-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aqp
    Allele (34)
    Strain: WBStrain00004916
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (40)
    Paralog: WBGene00000171 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000176 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000175 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013272 Caenorhabditis elegans From_analysis: Panther
      WBGene00000170 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000172 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000173 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000174 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa. Paper_evidence: WBPaper00005976
            WBPaper00028482
            WBPaper00029039
            WBPaper00030907
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 12 Aug 2007 00:00:00
      Automated_description: Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:636)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:0060180 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:640)
  Molecular_info: Corresponding_CDS: F32A5.5a
      F32A5.5b
    Corresponding_transcript: F32A5.5a.1
      F32A5.5b.1
    Other_sequence (15)
    Associated_feature: WBsf019168
      WBsf650216
      WBsf650217
      WBsf223316
  Experimental_info: RNAi_result: WBRNAi00097044 Inferred_automatically: RNAi_primary
      WBRNAi00094564 Inferred_automatically: RNAi_primary
      WBRNAi00014195 Inferred_automatically: RNAi_primary
      WBRNAi00063161 Inferred_automatically: RNAi_primary
      WBRNAi00031645 Inferred_automatically: RNAi_primary
      WBRNAi00046077 Inferred_automatically: RNAi_primary
      WBRNAi00097048 Inferred_automatically: RNAi_primary
      WBRNAi00094561 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4771
      Expr1017935
      Expr1149967
      Expr2009379
      Expr2027615
    Drives_construct: WBCnstr00012231
      WBCnstr00017137
      WBCnstr00037691
    Construct_product: WBCnstr00012231
      WBCnstr00017137
      WBCnstr00037691
    Microarray_results (25)
    Expression_cluster: WBPaper00027339:daf-12(rh273)_downregulated
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_zfp-1
      WBPaper00032430:rheb-1_regulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00036291:ung-1_regulated
      WBPaper00036738:4uM_Heme_downregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_adult_enriched
      WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00046795:starvation_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056165:mina-1(ok1521)_downregulated_transcript
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057254:MWCNT_upregulated_mRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060951:metr-1(os521)_downregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:AIM
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:C32F10.4-D1086.2
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065331:100nM-ivermectin_downregulated
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065841:3_5
      WBPaper00065841:26_0
      WBPaper00065841:26_1
      WBPaper00065877:rege-1(imm070)_downregulated_PA14
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065993:mml-1(RNAi)-neuron_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      cgc4386_cluster_1_3
      cgc4489_group_9
      WBPaper00005124:cholesterol_10-9M_regulated
      WBPaper00005124:progesterone_10-5M_regulated
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00006465:IV_ethanol_late_repression
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027111:rde-3(r459)_downregulated
      WBPaper00027111:rrf-3(pk1426)_downregulated
      WBPaper00028482:PA14_downregulated
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00031703:heme_responsive_4
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp3
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035479:glucose_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:TA300_up
      WBPaper00041211:RPW-24_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042234:xpa-1_upregulated
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_4h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045437:Toxic-Se_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00049311:Ag-MNP_regulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00050538:Fasting_upregulated_cholesterol-dependent
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_L1
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00053688:E.faecium_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5976]:class_1
      [cgc6390]:Cluster_A
    Interaction (92)
  Map_info: Map: II Position: 0.499703 Error: 3.1e-05
    Positive: Positive_clone: F32A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene