Questions, Feedback & Help

Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000169

expand all nodes | collapse all nodes | view schema

WBGene00000169	Evidence	Person_evidence	WBPerson548
	SMap	S_parent	Sequence	F32A5
	Identity	Version	2
		Name	CGC_name	aqp-1	Person_evidence	WBPerson300
			Sequence_name	F32A5.5
			Molecular_name	F32A5.5a
				F32A5.5a.1
				CE29304
				F32A5.5b
				CE01275
				F32A5.5b.1
			Other_name	dod-4
				CELE_F32A5.5	Accession_evidence	NDB	BX284602
			Public_name	aqp-1
		DB_info	Database	AceView	gene	2H526
				WormQTL	gene	WBGene00000169
				WormFlux	gene	WBGene00000169
				NDB	locus_tag	CELE_F32A5.5
				Panther	gene	CAEEL\|WormBase=WBGene00000169\|UniProtKB=Q19949
					family	PTHR43829
				NCBI	gene	174190
				RefSeq	protein	NM_063109.6
						NM_001381493.2
				TREEFAM	TREEFAM_ID	TF313173
				TrEMBL	UniProtAcc	Q19949
						Q8IG23
				UniProt_GCRP	UniProtAcc	Q19949
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:20	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	25 Aug 2004 11:36:28	WBPerson1971	Name_change	Other_name	dod-4
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	aqp
		Allele (34)
		Strain	WBStrain00004916
		RNASeq_FPKM (74)
		GO_annotation (23)
		Ortholog	WBGene00054302	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00033933	Caenorhabditis briggsae	From_analysis	OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00163936	Caenorhabditis brenneri	From_analysis	OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00092668	Pristionchus pacificus	From_analysis	OMA
			WBGene00128785	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			CBOVI.g7346	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g10390	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g6942	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g12174	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g9287	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g11887	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g6980	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g14314	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g25669	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g8359	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00001.g135	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-aqp-1	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold485.g1930	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00152.g5740	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_09478	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_006457	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g09218	Oscheius tipulae	From_analysis	WormBase-Compara
			Sp34_20259700	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrII_pilon.g4976	Caenorhabditis elegans	From_analysis	WormBase-Compara
			SGD:S000001840	Saccharomyces cerevisiae	From_analysis	Hieranoid
						OrthoInspector
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-030131-6461	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-040426-2826	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-040718-40	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-040724-66	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-070911-1	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-060503-57	Danio rerio	From_analysis	OMA
						OrthoFinder
						Panther
						PhylomeDB
			HGNC:636	Homo sapiens	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			HGNC:640	Homo sapiens	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			HGNC:643	Homo sapiens	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			HGNC:16029	Homo sapiens	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			HGNC:31976	Homo sapiens	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			MGI:1314647	Mus musculus	From_analysis	OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			RGD:2145	Rattus norvegicus	From_analysis	OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			RGD:68433	Rattus norvegicus	From_analysis	OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			RGD:68428	Rattus norvegicus	From_analysis	OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
		Paralog	WBGene00000171	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000176	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000175	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00013272	Caenorhabditis elegans	From_analysis	Panther
			WBGene00000170	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00000172	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00000173	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00000174	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa.	Paper_evidence	WBPaper00005976
						WBPaper00028482
						WBPaper00029039
						WBPaper00030907
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	12 Aug 2007 00:00:00
			Automated_description	Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:4724	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:636)
			DOID:8577	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:640)
			DOID:8778	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:640)
			DOID:9352	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:640)
			DOID:0060180	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:640)
			DOID:11981	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:640)
	Molecular_info	Corresponding_CDS	F32A5.5a
			F32A5.5b
		Corresponding_transcript	F32A5.5a.1
			F32A5.5b.1
		Other_sequence (15)
		Associated_feature	WBsf019168
			WBsf650216
			WBsf650217
			WBsf223316
	Experimental_info	RNAi_result	WBRNAi00097044	Inferred_automatically	RNAi_primary
			WBRNAi00094564	Inferred_automatically	RNAi_primary
			WBRNAi00014195	Inferred_automatically	RNAi_primary
			WBRNAi00063161	Inferred_automatically	RNAi_primary
			WBRNAi00031645	Inferred_automatically	RNAi_primary
			WBRNAi00046077	Inferred_automatically	RNAi_primary
			WBRNAi00097048	Inferred_automatically	RNAi_primary
			WBRNAi00094561	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr4771
			Expr1017935
			Expr1149967
			Expr2009379
			Expr2027615
		Drives_construct	WBCnstr00012231
			WBCnstr00017137
			WBCnstr00037691
		Construct_product	WBCnstr00012231
			WBCnstr00017137
			WBCnstr00037691
		Microarray_results (25)
		Expression_cluster (279)
		Interaction (92)
	Map_info	Map	II	Position	0.499703	Error	3.1e-05
		Positive	Positive_clone	F32A5	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (15)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene