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WormBase Tree Display for Gene: WBGene00000170

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Name Class

WBGene00000170EvidencePerson_evidenceWBPerson548
SMapS_parentSequenceC01G6
IdentityVersion1
NameCGC_nameaqp-2Person_evidenceWBPerson300
Sequence_nameC01G6.1
Molecular_nameC01G6.1a
C01G6.1a.1
CE00863
C01G6.1b
CE19664
C01G6.1b.1
C01G6.1b.2
Other_nameCELE_C01G6.1Accession_evidenceNDBBX284602
Public_nameaqp-2
DB_infoDatabaseAceViewgene2J550
WormQTLgeneWBGene00000170
WormFluxgeneWBGene00000170
NDBlocus_tagCELE_C01G6.1
PanthergeneCAEEL|WormBase=WBGene00000170|UniProtKB=Q17571
familyPTHR43829
NCBIgene174467
RefSeqproteinNM_001393149.1
NM_001381560.2
TREEFAMTREEFAM_IDTF313173
TrEMBLUniProtAccQ17571
Q7JMQ6
UniProt_GCRPUniProtAccQ17571
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaqp
Allele (52)
StrainWBStrain00032407
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (47)
ParalogWBGene00000169Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000176Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000175Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013272Caenorhabditis elegansFrom_analysisPanther
WBGene00000171Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000172Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000173Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000174Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionaqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress.Paper_evidenceWBPaper00003343
WBPaper00013089
WBPaper00025051
WBPaper00027009
WBPaper00027351
WBPaper00029039
WBPaper00030907
Curator_confirmedWBPerson1843
Date_last_updated12 Aug 2007 00:00:00
Automated_descriptionEnables water channel activity. Involved in water transport. Predicted to be located in basolateral plasma membrane. Expressed in excretory cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4724Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:636)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:0060180Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:11981Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
Molecular_infoCorresponding_CDSC01G6.1a
C01G6.1b
Corresponding_transcriptC01G6.1a.1
C01G6.1b.1
C01G6.1b.2
Other_sequence (55)
Associated_feature (22)
Experimental_infoRNAi_result (13)
Expr_patternExpr4772
Expr1017046
Expr1030096
Expr1143468
Expr2009380
Expr2027616
Drives_constructWBCnstr00012232
WBCnstr00037690
Construct_productWBCnstr00037690
Microarray_results (37)
Expression_clusterWBPaper00032031:DConiospora_downregulated_cDNA_12h
WBPaper00032031:DConiospora_downregulated_cDNA_24h
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00032528:L3_enriched
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L3
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046795:starvation_upregulated
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00046805:csr-1(RNAi)_downregulated_Set2
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050094:mes-6(bn66)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051388:Glucose-diet_upregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:female_vs_male_downregulated
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00054192:cold-shock_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00055981:fog-2(q71)_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059763:neuron_expressed
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061040:FW1256_downregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Body_wall_muscle
WBPaper00061340:BWM_anterior
WBPaper00061340:CEPsh
WBPaper00061340:CEPso
WBPaper00061340:Excretory_cell
WBPaper00061340:Excretory_duct_and_pore
WBPaper00061340:Excretory_gland
WBPaper00061340:F_U
WBPaper00061340:Glia
WBPaper00061340:GLR
WBPaper00061340:hyp3
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061340:ILso
WBPaper00061340:Intestinal_and_rectal_muscle
WBPaper00061340:K_Kprime
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061466:nath-10(icb99)_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:hda-1(ne4747)_upregulated
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061479:hrde-1(tm1200)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:unc-44_403-H24G06.1_2859
WBPaper00061651:AS_enriched
WBPaper00061651:AVG_enriched
WBPaper00061651:CEPsh_enriched
WBPaper00061651:DA9_enriched
WBPaper00061651:DA_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:IL2_LR_enriched
WBPaper00061651:M3_enriched
WBPaper00061651:PHB_enriched
WBPaper00061651:PHso_enriched
WBPaper00061651:PVD_enriched
WBPaper00061651:PVT_enriched
WBPaper00061651:PVW_enriched
WBPaper00061651:XXX_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:etr-1(lq61)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00062684:pathogen_upregulated_N2
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064201:SNA-3_interacting
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064871:hypoxia_downregulated_F3
WBPaper00065029:cadmium_upregulated
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:25C_vs_15C_upregulated_AFD
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065392:Lb.gasseri_downregulated
WBPaper00065392:P.pentosaceus_downregulated
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
WBPaper00065841:14_0
WBPaper00065841:38_0
WBPaper00065841:38_1
WBPaper00065841:40_0
WBPaper00065841:64_0
WBPaper00065841:131_0
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066093:E.coli-purE_downregulated
WBPaper00066232:ash-2(RNAi)_upregulated_WT
cgc4386_cluster_6_2
WBPaper00025032:cluster_24
WBPaper00025032:cluster_60
WBPaper00025032:PAL-1_target_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00027111:rrf-1(pk1417)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00031003:hlh_1_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00033101:spr-5_regulated
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-7_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035873:osm-11_regulated
WBPaper00038060:SUMO-1_downregulated
WBPaper00038304:octr-1_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_2.0mM_Down
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041960:N2_fasting_upregulated_9hto12h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042236:flcn-1(ok975)_upregulated
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00046639:tyrosol_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00050767:Octopamine_induced
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_5
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_SE
[cgc5767]:expression_class_SE_pi(53_min)
Interaction (19)
Map_infoMapIIPosition1.09711Error0.000462
PositivePositive_cloneC01G6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (13)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene