The ife-1 gene encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; it is specifically required for spermatogenesis, and is expressed in P granules.
Enables RNA 7-methylguanosine cap binding activity and RNA trimethylguanosine cap binding activity. Involved in embryo development; oocyte maturation; and spermatid development. Located in P granule. Expressed in germ line; gonad; oocyte; primary spermatocyte; and secondary spermatocyte. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.