dnj-7 encodes a protein containing a DnaJ domain that is orthologous to vertebrate P58IPK/DNAJC3, peripheral membrane proteins of the rough endoplasmic reticulum (ER) that function in co-translocational ER protein degradation during ER stress; in C. elegans, loss of dnj-7 activity via RNAi results in increased expression of an hsp-4::gfp (BiP) stress-inducible reporter fusion, suggesting that dnj-7 functions to regulate ER homeostasis.
Predicted to enable misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Expressed in head. Is an ortholog of human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.