WormBase Tree Display for Gene: WBGene00001032
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| WBGene00001032 | SMap | S_parent | Sequence | K02G10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dnj-14 | Person_evidence | WBPerson625 | |||||
| Sequence_name | K02G10.8 | ||||||||
| Molecular_name | K02G10.8a | ||||||||
| K02G10.8a.1 | |||||||||
| CE04708 | |||||||||
| K02G10.8b | |||||||||
| CE45638 | |||||||||
| K02G10.8b.1 | |||||||||
| Other_name | CELE_K02G10.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dnj-14 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dnj | ||||||||
| Allele (37) | |||||||||
| Possibly_affected_by | WBVar02158624 | ||||||||
| WBVar02158625 | |||||||||
| WBVar02158626 | |||||||||
| Strain | WBStrain00033400 | ||||||||
| WBStrain00037702 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00008223 | ||||||||
| 00008224 | |||||||||
| 00008225 | |||||||||
| 00008226 | |||||||||
| 00008227 | |||||||||
| 00008228 | |||||||||
| 00008229 | |||||||||
| Ortholog (44) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Automated_description | Involved in determination of adult lifespan; locomotion; and neurotransmitter secretion. Predicted to be located in type Is terminal bouton. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Is an ortholog of human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) and DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14503 | Homo sapiens | Paper_evidence | WBPaper00045410 | ||||
| Accession_evidence | OMIM | 162350 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
| Potential_model | DOID:0110720 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16235) | |||||
| Disease_relevance | Mutations in human DNAJC5 are implicated in adult onset neuronal lipofuscinosis (ANCL; Kufs disease and Parry disease), a neurodegenerative disorder characterised by progressive neuronal dysfunction and premature death; DNAJC5 encodes an evolutionarily conserved member of the DnaJ/Hsp40 family of molecular chaperones known as cysteine string protein (CSP); in C. elegans, mutants of dnj-14 (tm3223, ok237), which is orthologous to human DNAJC5, show reduced life-span, impaired locomotion, reduced neurotransmission and impaired chemosensation; older dnj-14 animals exhibited neuronal abnormalities like loss of neuronal cell bodies, reduction in the number of visible neurites, and the presence of contorted neuronal processes; use of this dnj-14 model identified resveratrol as a compound that could extend dnj-14 mutant lifespan, partially rescue the neurodegeneration phenotype and significantly ameliorate the chemotaxis defects of dnj-14 mutants; this resveratrol activity was mimicked by phosphodiesterase inhibition and independent of SIR-2.1/Sirtuin, unlike in other C. elegans neurodegeneration models where resveratrol activity was shown to be sir-2.1 dependent. | Homo sapiens | Paper_evidence | WBPaper00045410 | |||||
| Accession_evidence | OMIM | 611203 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000331 | ||||||||
| WBDOannot00000409 | |||||||||
| WBDOannot00000410 | |||||||||
| Molecular_info | Corresponding_CDS | K02G10.8a | |||||||
| K02G10.8b | |||||||||
| Corresponding_transcript | K02G10.8a.1 | ||||||||
| K02G10.8b.1 | |||||||||
| Other_sequence (30) | |||||||||
| Associated_feature | WBsf653929 | ||||||||
| WBsf670453 | |||||||||
| WBsf982161 | |||||||||
| WBsf237308 | |||||||||
| WBsf237309 | |||||||||
| WBsf237310 | |||||||||
| WBsf237311 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016500 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00106560 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106561 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106329 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033900 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076542 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049772 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1021089 | ||||||||
| Expr1030644 | |||||||||
| Expr1153487 | |||||||||
| Expr2010988 | |||||||||
| Expr2029226 | |||||||||
| Drives_construct | WBCnstr00042947 | ||||||||
| Regulate_expr_cluster | WBPaper00048567:dnj-14_downregulated | ||||||||
| WBPaper00048567:dnj-14_upregulated | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (44) | |||||||||
| Map_info | Map | X | Position | -6.83097 | Error | 0.016329 | |||
| Positive | Positive_clone | K02G10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4264 | |||||||
| 5084 | |||||||||
| 5264 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
