WormBase Tree Display for Gene: WBGene00001045
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| WBGene00001045 | SMap | S_parent | Sequence | Y47H9C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dnj-27 | Person_evidence | WBPerson625 | |||||
| Sequence_name | Y47H9C.5 | ||||||||
| Molecular_name | Y47H9C.5a | ||||||||
| Y47H9C.5a.1 | |||||||||
| CE20265 | |||||||||
| Y47H9C.5b | |||||||||
| CE40162 | |||||||||
| Y47H9C.5b.1 | |||||||||
| Other_name | CELE_Y47H9C.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | dnj-27 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00001045 | |||||
| WormFlux | gene | WBGene00001045 | |||||||
| NDB | locus_tag | CELE_Y47H9C.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001045|UniProtKB=Q9XWE1 | |||||||
| family | PTHR44340 | ||||||||
| NCBI | gene | 173065 | |||||||
| RefSeq | protein | NM_001047239.4 | |||||||
| NM_001047240.3 | |||||||||
| TREEFAM | TREEFAM_ID | TF105169 | |||||||
| TrEMBL | UniProtAcc | Q9XWE1 | |||||||
| Q25AR9 | |||||||||
| UniProt_GCRP | UniProtAcc | Q9XWE1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dnj | ||||||||
| Allele (171) | |||||||||
| Strain | WBStrain00001449 | ||||||||
| WBStrain00032475 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | This gene encodes a protein containing a DnaJ ('J') domain. | Paper_evidence | WBPaper00012768 | |||||
| WBPaper00012859 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable misfolded protein binding activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; and protein-disulfide reductase activity. Involved in IRE1-mediated unfolded protein response. Located in endoplasmic reticulum lumen. Expressed in several structures, including body wall musculature; gonadal sheath cell; intestine; rectum; and vulva. Is an ortholog of human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Disease_relevance | Misfolded and aggregation-prone proteins are implicated in the initiation and progression of many neurodegenerative diseases like Alzheimer''s, Parkinson''s and Huntington''s diseases; studies in transgenic elegans models of these diseases, have identified dnj-27, ortholog of mammalian ERdj5, as an endoplasmic reticulum (ER) expressed thioredoxin protein required for the degradation of misfolded proteins; RNA interference of elegans dnj-27 increases the aggregation and associated pathological phenotypes of paralysis and motility defects caused by human beta-amyloid peptide, human alpha-synuclein and polyglutamine (polyQ) proteins, while overexpression of elegans dnj-27 ameliorates the phenotypes; further dnj-27 down-regulation alters cytoplasmic protein homeostasis and causes mitochondrial fragmentation. | Homo sapiens | Paper_evidence | WBPaper00042360 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Jan 2015 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y47H9C.5a | |||||||
| Y47H9C.5b | |||||||||
| Corresponding_transcript | Y47H9C.5a.1 | ||||||||
| Y47H9C.5b.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf654829 | ||||||||
| WBsf985404 | |||||||||
| WBsf985405 | |||||||||
| WBsf985406 | |||||||||
| WBsf1010799 | |||||||||
| WBsf1010800 | |||||||||
| WBsf1010801 | |||||||||
| WBsf1010802 | |||||||||
| WBsf218564 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00037210 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00108398 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056850 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108375 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108379 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106342 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108378 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058311 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr6995 | ||||||||
| Expr11009 | |||||||||
| Expr1027217 | |||||||||
| Expr1030657 | |||||||||
| Expr1160301 | |||||||||
| Expr2011002 | |||||||||
| Expr2029240 | |||||||||
| Drives_construct | WBCnstr00002331 | ||||||||
| WBCnstr00017696 | |||||||||
| WBCnstr00017697 | |||||||||
| WBCnstr00017698 | |||||||||
| WBCnstr00017980 | |||||||||
| WBCnstr00017981 | |||||||||
| Construct_product | WBCnstr00017980 | ||||||||
| WBCnstr00017981 | |||||||||
| WBCnstr00038139 | |||||||||
| Antibody | WBAntibody00002463 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction (30) | |||||||||
| WBProcess | WBbiopr:00000076 | ||||||||
| Map_info | Map | I | Position | 12.892 | Error | 0.004864 | |||
| Positive | Positive_clone | Y47H9C | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00036931 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039115 | |||||||||
| WBPaper00042360 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
