WormBase Tree Display for Gene: WBGene00003730

WBGene00003730 SMap: S_parent: Sequence: B0495
  Identity: Version: 1
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhx
    Allele: WBVar01499702
      WBVar00268834
      WBVar01405294
      WBVar01498435
      WBVar00091840
      WBVar01492220
      WBVar02130273
      WBVar00238266
      WBVar00225884
      WBVar01375745
      WBVar00745624
      WBVar00745625
      WBVar00745626
      WBVar00745627
      WBVar00745628
      WBVar00745629
      WBVar00745630
      WBVar00745631
      WBVar00745632
      WBVar00745633
      WBVar00745634
      WBVar00745635
      WBVar00173556
      WBVar00173557
      WBVar00745636
      WBVar00173558
      WBVar00745637
      WBVar00745638
      WBVar00745639
      WBVar00370656
      WBVar00370657
      WBVar00370658
      WBVar01498940
      WBVar01393817
    Strain: WBStrain00035710
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog (49)
    Paralog: WBGene00003729 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003736 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003733 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003735 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003731 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003943 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003734 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00003732 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: nhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells. Paper_evidence: WBPaper00005421
            WBPaper00005654
            WBPaper00006186
            WBPaper00040287
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 21 Oct 2011 00:00:00
      Automated_description: Enables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:783 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11078)
      DOID:0080065 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11071)
      DOID:6000 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11071)
      DOID:0060777 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11073)
  Molecular_info: Corresponding_CDS: B0495.4
    Corresponding_CDS_history: B0495.4:wp239
    Corresponding_transcript: B0495.4.1
    Other_sequence (11)
    Associated_feature: WBsf988538
      WBsf988539
      WBsf1012587
      WBsf223370
  Experimental_info: RNAi_result (40)
    Expr_pattern: Expr113
      Expr2233
      Expr2241
      Expr8046
      Expr1020516
      Expr1031742
      Expr1143268
      Expr2014254
      Expr2032494
    Drives_construct (47)
    Construct_product: WBCnstr00009193
      WBCnstr00010721
      WBCnstr00019888
      WBCnstr00035911
    Antibody: WBAntibody00002657
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_downregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00038061:aldicarb_downregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044005:DAF-16_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_specific
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:Cadmium_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:SIB
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061405:S.aureus_upregulated_starvation
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062078:NMR-HspB1_regulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062590:Aging_upregulated_coelomocyte
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064789:Day3_vs_Day1_upregulated_neuron
      WBPaper00064789:Day6_vs_Day1_upregulated_neuron
      WBPaper00064789:Day9_vs_Day1_upregulated_neuron
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:12_0
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066118:cyclobutrifluram_downregulated
      cgc4386_cluster_1_2
      cgc4489_group_7
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025099:NI_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035504:daf-2(e1370)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_repressed_4h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc6390]:Cluster_C
      [cgc6390]:herm_soma-enriched
    Interaction (36)
  Map_info: Map: II Position: 0.523763 Error: 0.005206
    Positive: Positive_clone: B0495 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4530
        5562
    Pseudo_map_position
  Reference (26)
  Remark: Sequence connection from [Nehrke K, Melvin J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes CGC_data_submission
  Method: Gene