WormBase Tree Display for Gene: WBGene00003731
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| WBGene00003731 | SMap | S_parent | Sequence | C54F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhx-3 | |||||||
| Sequence_name | C54F6.13 | ||||||||
| Molecular_name | C54F6.13a | ||||||||
| C54F6.13a.1 | |||||||||
| CE32044 | |||||||||
| C54F6.13b | |||||||||
| CE08985 | |||||||||
| C54F6.13a.2 | |||||||||
| C54F6.13b.1 | |||||||||
| Other_name | CELE_C54F6.13 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | nhx-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhx | ||||||||
| Allele (56) | |||||||||
| Strain | WBStrain00036007 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (53) | |||||||||
| Paralog | WBGene00003729 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003730 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003736 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003733 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003943 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003734 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003732 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | nhx-3 encodes a sodium/proton exchanger expressed intracellularly (in elliptical, randomly distributed dots that might be multivesicular or Ward bodies) within hypodermal cells of the main body syncytium, socket cells, and the excretory pore cell, as well as (in adults) within uterine cells (probably ut1) in the region closest to the vulva, in spermathecal junction cells; nhx-3 has no obvious phenotype in mass RNAi screens; NHX-3 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; speculatively, NHX-3 might enable hypodermis-specific secretion of cuticle or phagocytosis. | Paper_evidence | WBPaper00005421 | |||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in plasma membrane. Expressed in epithelial cell; hypodermis; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8 and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11078) | ||||
| DOID:0060777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11073) | ||||||
| Molecular_info | Corresponding_CDS | C54F6.13a | |||||||
| C54F6.13b | |||||||||
| Corresponding_CDS_history | C54F6.13:wp87 | ||||||||
| Corresponding_transcript | C54F6.13a.1 | ||||||||
| C54F6.13a.2 | |||||||||
| C54F6.13b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf652778 | ||||||||
| WBsf233955 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00030150 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00107732 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00107733 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043163 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012401 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115930 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2236 | ||||||||
| Expr2245 | |||||||||
| Expr1013171 | |||||||||
| Expr1147139 | |||||||||
| Expr2014255 | |||||||||
| Expr2032495 | |||||||||
| Drives_construct | WBCnstr00010715 | ||||||||
| WBCnstr00010725 | |||||||||
| WBCnstr00035910 | |||||||||
| Construct_product | WBCnstr00010725 | ||||||||
| WBCnstr00035910 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (129) | |||||||||
| Interaction (16) | |||||||||
| Map_info | Map | V | Position | 0.773277 | Error | 0.003626 | |||
| Positive | Positive_clone | C54F6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5336 | |||||||
| 5364 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00032165 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049246 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065561 | |||||||||
| Remark | Sequence connection from [Nehrke K, Melvin J] | ||||||||
| nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes | CGC_data_submission | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
