WormBase Tree Display for Gene: WBGene00003730
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| WBGene00003730 | SMap | S_parent | Sequence | B0495 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhx-2 | |||||||
| Sequence_name | B0495.4 | ||||||||
| Molecular_name | B0495.4 | ||||||||
| B0495.4.1 | |||||||||
| CE48832 | |||||||||
| Other_name | CELE_B0495.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | nhx-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhx | ||||||||
| Allele (34) | |||||||||
| Strain | WBStrain00035710 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00003729 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003736 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003733 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003731 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003943 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003734 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003732 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | nhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells. | Paper_evidence | WBPaper00005421 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006186 | |||||||||
| WBPaper00040287 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 21 Oct 2011 00:00:00 | ||||||||
| Automated_description | Enables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11078) | ||||
| DOID:0080065 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11071) | ||||||
| DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11071) | ||||||
| DOID:0060777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11073) | ||||||
| Molecular_info | Corresponding_CDS | B0495.4 | |||||||
| Corresponding_CDS_history | B0495.4:wp239 | ||||||||
| Corresponding_transcript | B0495.4.1 | ||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf988538 | ||||||||
| WBsf988539 | |||||||||
| WBsf1012587 | |||||||||
| WBsf223370 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern | Expr113 | ||||||||
| Expr2233 | |||||||||
| Expr2241 | |||||||||
| Expr8046 | |||||||||
| Expr1020516 | |||||||||
| Expr1031742 | |||||||||
| Expr1143268 | |||||||||
| Expr2014254 | |||||||||
| Expr2032494 | |||||||||
| Drives_construct (47) | |||||||||
| Construct_product | WBCnstr00009193 | ||||||||
| WBCnstr00010721 | |||||||||
| WBCnstr00019888 | |||||||||
| WBCnstr00035911 | |||||||||
| Antibody | WBAntibody00002657 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (213) | |||||||||
| Interaction (36) | |||||||||
| Map_info | Map | II | Position | 0.523763 | Error | 0.005206 | |||
| Positive | Positive_clone | B0495 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4530 | |||||||
| 5562 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Sequence connection from [Nehrke K, Melvin J] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes | CGC_data_submission | ||||||||
| Method | Gene |
