WormBase Tree Display for Gene: WBGene00003733
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| WBGene00003733 | SMap | S_parent | Sequence | F57C7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhx-5 | |||||||
| Sequence_name | F57C7.2 | ||||||||
| Molecular_name | F57C7.2a | ||||||||
| F57C7.2a.1 | |||||||||
| CE31014 | |||||||||
| F57C7.2b | |||||||||
| CE31015 | |||||||||
| F57C7.2b.1 | |||||||||
| F57C7.2b.2 | |||||||||
| F57C7.2b.3 | |||||||||
| Other_name | CELE_F57C7.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nhx-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhx | ||||||||
| Allele (64) | |||||||||
| Possibly_affected_by | WBVar02152892 | ||||||||
| Strain | WBStrain00001727 | ||||||||
| WBStrain00031549 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00003729 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003730 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003731 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003732 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003736 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003734 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003943 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | nhx-5 encodes a sodium/proton exchanger expressed intracellularly in many neurons, as well as in the vulC cells of the vulva and the excretory cell; nhx-5 has no obvious phenotype in mass RNAi screens; NHX-5 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; the granular intracellular expression of NHX-5::GFP suggests association with some cytoplasmic organelle specifically required for neuronal function. | Paper_evidence | WBPaper00005421 | |||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in plasma membrane and recycling endosome. Expressed in several structures, including HSN; excretory cell; ganglia; ventral nerve cord; and vulC. Human ortholog(s) of this gene implicated in Christianson syndrome; X-linked intellectual developmental disorder 108; and autistic disorder. Is an ortholog of human SLC9A9 (solute carrier family 9 member A9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11079) | ||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20653) | ||||||
| DOID:0111844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17123) | ||||||
| Molecular_info | Corresponding_CDS | F57C7.2a | |||||||
| F57C7.2b | |||||||||
| Corresponding_CDS_history | F57C7.2:wp80 | ||||||||
| Corresponding_transcript | F57C7.2a.1 | ||||||||
| F57C7.2b.1 | |||||||||
| F57C7.2b.2 | |||||||||
| F57C7.2b.3 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf648487 | ||||||||
| WBsf655209 | |||||||||
| WBsf662386 | |||||||||
| WBsf1006748 | |||||||||
| WBsf236296 | |||||||||
| WBsf236297 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00086174 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00048860 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086172 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033031 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram561 | ||||||||
| Expr2239 | |||||||||
| Expr2246 | |||||||||
| Expr13003 | |||||||||
| Expr1012874 | |||||||||
| Expr1031744 | |||||||||
| Expr1152609 | |||||||||
| Expr2014257 | |||||||||
| Expr2032497 | |||||||||
| Drives_construct | WBCnstr00002554 | ||||||||
| WBCnstr00010718 | |||||||||
| WBCnstr00010726 | |||||||||
| WBCnstr00035908 | |||||||||
| WBCnstr00038143 | |||||||||
| Construct_product | WBCnstr00010726 | ||||||||
| WBCnstr00035908 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | X | Position | 2.27758 | Error | 0.011586 | |||
| Positive | Positive_clone | F57C7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4532 | |||||||
| 4652 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00049870 | |||||||||
| WBPaper00051803 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00066025 | |||||||||
| Remark | Sequence connection from [Nehrke K, Melvin J] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes | CGC_data_submission | ||||||||
| Method | Gene |
