| WBGene00020307 | SMap | S_parent | Sequence | T07D3 |
|---|
| Identity | Version | 1 |
| | Name | Sequence_name | T07D3.4 |
| | | Molecular_name | T07D3.4a |
| | | | T07D3.4a.1 |
| | | | CE13361 |
| | | | T07D3.4b |
| | | | CE51164 |
| | | | T07D3.4b.1 |
| | | Other_name | CELE_T07D3.4 | Accession_evidence | NDB | BX284602 |
| | | Public_name | T07D3.4 |
| | DB_info | Database | AceView | gene | 2B179 |
| | | | WormQTL | gene | WBGene00020307 |
| | | | WormFlux | gene | WBGene00020307 |
| | | | OMIM | disease | 253800 |
| | | | | | 611588 |
| | | | | | 611615 |
| | | | | | 613152 |
| | | | | gene | 607440 |
| | | | NDB | locus_tag | CELE_T07D3.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00020307|UniProtKB=O16723 |
| | | | | family | PTHR15407 |
| | | | NCBI | gene | 173469 |
| | | | RefSeq | protein | NM_061439.7 |
| | | | | | NM_001318301.3 |
| | | | TrEMBL | UniProtAcc | O16723 |
| | | | | | A0A0S4XRC0 |
| | | | UniProt_GCRP | UniProtAcc | O16723 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Allele (167) |
| | Strain | WBStrain00031550 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00001837 |
| | Ortholog (57) |
| | Paralog | WBGene00011554 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00017877 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00020924 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00021249 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00020309 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00020308 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | WBGene00020927 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00045475 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | T07D3.4 is orthologous to the human gene, Fukutin (FKTN, also called FCMD). | Paper_evidence | WBPaper00038491 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 07 Jun 2012 00:00:00 |
| | | Automated_description | Predicted to be involved in protein glycosylation. Human ortholog(s) of this gene implicated in Fukuyama congenital muscular dystrophy; Walker-Warburg syndrome; autosomal recessive limb-girdle muscular dystrophy type 2L; autosomal recessive limb-girdle muscular dystrophy type 2M; dilated cardiomyopathy (multiple); and muscular dystrophy-dystroglycanopathy type B4. Is an ortholog of human FKTN (fukutin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0050560 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0050559 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0110443 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0112379 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0110296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0110444 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | | DOID:0110284 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3622) |
| | Disease_relevance | The human ortholog of elegans TO7D3.4, Fukutin, is required for normal glycosylation of the cell surface laminin receptor, alpha-dystroglycan; mutations in Fukutin cause cardiomyopathy and Fukuyama-type congenital muscular dystrophy (FCMD), an inherited condition that predominantly affects the muscles, brain, and eyes, due to weakness and wasting of skeletal muscles. | Homo sapiens | Accession_evidence | OMIM | 611615 |
| | | | | | | 253800 |
| | | | | | | 613152 |
| | | | | | | 611588 |
| | | | | | | 607440 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 11 Jun 2012 00:00:00 |
| Molecular_info | Corresponding_CDS | T07D3.4a |
| | | T07D3.4b |
| | Corresponding_transcript | T07D3.4a.1 |
| | | T07D3.4b.1 |
| | Other_sequence | Oden_isotig15156 |
| | | Oden_isotig21890 |
| | | Dviv_isotig31365 |
| | Associated_feature | WBsf643929 |
| | | WBsf643930 |
| | | WBsf986513 |
| | | WBsf986514 |
| | | WBsf986515 |
| | | WBsf1011453 |
| | | WBsf1011454 |
| | | WBsf220796 |
| Experimental_info | RNAi_result | WBRNAi00035302 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00052752 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00018361 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115898 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1013786 |
| | | Expr1038847 |
| | | Expr1156361 |
| | | Expr2005965 |
| | | Expr2024181 |
| | Drives_construct | WBCnstr00025231 |
| | Construct_product | WBCnstr00025231 |
| | Microarray_results (15) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00035211:age-1_vs_N2_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:intestine_CoreEnriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00038104:DATS_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046024:sleep_downregulated_oscillating |
| | | WBPaper00046121:endoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:TCER-1_downregulated |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049368:daf-2(e1370)_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053909:N2_vs_CB4856_upregulated |
| | | WBPaper00054872:egl-9(sa307)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056284:ints-4(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059253:sucrose_downregulated |
| | | WBPaper00059253:sucrose_stearic-acid_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061527:C24A3.4_16071-ech-8 |
| | | WBPaper00061651:Rectal_gland_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065199:Transgeneration-starvation_regulated_fed |
| | | WBPaper00065315:mating_downregulated_Day2-7 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:3_4 |
| | | WBPaper00065841:3_5 |
| | | WBPaper00065841:30_0 |
| | | WBPaper00065841:30_3 |
| | | WBPaper00065841:30_4 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066204:CdCl2_upregulated_mRNA |
| | | WBPaper00025032:cluster_16 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00037695:CC_3-day |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:jun-1_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00044535:male_downregulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction | WBInteraction000389723 |
| | | WBInteraction000446865 |
| Map_info | Positive | Positive_clone | T07D3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Interpolated_map_position | II | -15.5897 |
| Reference | WBPaper00038491 |
| | WBPaper00055090 |
| | WBPaper00062840 |
| Method | Gene |
