jud-4 encodes an unfamiliar protein, putatively secreted, that isrequired both for normal sensitivity to ethanol and for survival afterfreezing and thawing; JUD-4 is expressed in hypodermis and vulvalmuscles; JUD-4 is orthologous to Brugia malayi Bm1_40315, but lacksobvious orthologies to non-nematode proteins; JUD-4's C-terminal domainhas possible similarity to F40E10.5, and to proteins such as human HOMER1; jud-4(ys18) mutants show delayed sensitivity to ethanol levelsthat rapidly paralyze normal worms, but do not survive freezing andrethawing as does wild-type; JUD-4 has no obvious function in mass RNAi assays.