WormBase Tree Display for Gene: WBGene00004316

WBGene00004316 SMap: S_parent: Sequence: F37A4
  Identity: Version: 1
    Name: CGC_name: rbf-1 Person_evidence: WBPerson451
      Sequence_name: F37A4.7
      Molecular_name (14)
      Other_name: Rabph Paper_evidence: WBPaper00013595
        CELE_F37A4.7 Accession_evidence: NDB BX284603
      Public_name: rbf-1
    DB_info: Database: AceView gene 3H793
        WormQTL gene WBGene00004316
        WormFlux gene WBGene00004316
        NDB locus_tag CELE_F37A4.7
        Panther gene CAEEL|WormBase=WBGene00004316|UniProtKB=P41885
          family PTHR45729
        NCBI gene 175943
        RefSeq protein NM_001392126.1
            NM_001027396.5
            NM_001379772.1
            NM_001027395.5
        SwissProt UniProtAcc P41885
        TREEFAM TREEFAM_ID TF351844
        UniProt_GCRP UniProtAcc P41885
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rbf
    Allele (346)
    Strain: WBStrain00029052
      WBStrain00037267
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (51)
    Paralog: WBGene00004921 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004922 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004923 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004924 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004925 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004926 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006306 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011682 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020861 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rbf-1 encodes the sole C. elegans rabphilin homolog; rbf-1 activity is required for normal basal rates of locomotion (in the absence of stimulation) and, in combination with SNARE components ric-4, snb-1, and unc-64, for normal rates of both basal and stimulated locomotion; RBF-1 is expressed in the nerve ring and in the dorsal and ventral nerve cords and colocalizes with synaptic vesicle markers. Paper_evidence: WBPaper00004976
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Jun 2007 00:00:00
      Automated_description: Predicted to enable metal ion binding activity. Involved in dense core granule exocytosis and positive regulation of locomotion. Located in synaptic vesicle. Expressed in dorsal nerve cord; nerve ring; neurons; and ventral nerve cord. Is an ortholog of human RPH3A (rabphilin 3A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F37A4.7a
      F37A4.7b
      F37A4.7c
      F37A4.7d
    Corresponding_CDS_history: F37A4.7d:wp275
    Corresponding_transcript: F37A4.7a.1
      F37A4.7a.2
      F37A4.7a.3
      F37A4.7b.1
      F37A4.7c.1
      F37A4.7d.1
    Other_sequence (48)
    Associated_feature (35)
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr1718
      Expr1719
      Expr3633
      Expr1024340
      Expr1032141
      Expr1150454
      Expr2015267
      Expr2033501
    Drives_construct: WBCnstr00000698
      WBCnstr00010412
    Construct_product: WBCnstr00000698
      WBCnstr00007721
      WBCnstr00010412
      WBCnstr00011558
    Antibody: WBAntibody00000428
    Microarray_results (43)
    Expression_cluster: WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051305:vit-2(ac3)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059203:CAR-1_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:AFD
      WBPaper00061340:AIA
      WBPaper00061340:AIY
      WBPaper00061340:ALM_PLM
      WBPaper00061340:ASE
      WBPaper00061340:AUA
      WBPaper00061340:AVD
      WBPaper00061340:AVH
      WBPaper00061340:AVJ
      WBPaper00061340:AVK
      WBPaper00061340:BAG
      WBPaper00061340:OLL
      WBPaper00061340:PVP
      WBPaper00061340:RIS
      WBPaper00061340:SIB
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:xbx-3-DH11.5_20397
      WBPaper00061651:AFD_enriched
      WBPaper00061651:ASEL_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:20_1
      WBPaper00065841:49_0
      WBPaper00065841:66_0
      WBPaper00065841:74_0
      WBPaper00065841:93_0
      WBPaper00065841:108_0
      WBPaper00065841:115_0
      WBPaper00065841:126_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (27)
  Map_info: Map: III Position: -1.01086 Error: 0.003652
    Positive: Positive_clone: F37A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4626
        4987
        5453
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene