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WormBase Tree Display for Gene: WBGene00003654

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Name Class

WBGene00003654EvidencePaper_evidenceWBPaper00003416
SMapS_parentSequenceC45E1
IdentityVersion1
NameCGC_namenhr-64Person_evidenceWBPerson600
Sequence_nameC45E1.1
Molecular_nameC45E1.1a
C45E1.1a.1
CE39696
C45E1.1b
CE39697
C45E1.1c
CE52156
C45E1.1a.2
C45E1.1b.1
C45E1.1c.1
Other_nameCELE_C45E1.1Accession_evidenceNDBBX284601
Public_namenhr-64
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
AlleleWBVar00027751
WBVar01545909
WBVar00027761
WBVar02011333
WBVar02109568
WBVar02109569
WBVar00299343
WBVar02039337
WBVar02039338
WBVar02039339
WBVar02039340
WBVar02039341
WBVar01280389
WBVar00027786
WBVar01280391
WBVar01280392
WBVar00027791
WBVar01280394
WBVar01280396
WBVar01280398
WBVar02106086
WBVar01280399
WBVar01280400
WBVar02083823
WBVar02083824
WBVar01280401
WBVar01280402
WBVar00027801
WBVar01280403
WBVar01280404
WBVar01280405
WBVar00151762
WBVar01280407
WBVar00151764
WBVar00151765
WBVar01280408
WBVar00151766
WBVar01280409
WBVar00317277
WBVar00027811
WBVar01280410
WBVar02009780
WBVar00151767
WBVar00151768
WBVar02009781
WBVar00151769
WBVar00151771
WBVar00151772
WBVar00027821
WBVar00151773
WBVar00151774
WBVar00151775
WBVar00151776
WBVar00027826
WBVar00151777
WBVar00151778
WBVar01391780
WBVar01391781
WBVar01271028
WBVar02028410
WBVar01271361
WBVar01391782
WBVar02028411
WBVar01391783
WBVar02028413
WBVar00250123
WBVar01691747
WBVar01411359
WBVar01411361
WBVar01411362
WBVar00097344
WBVar00097345
WBVar00097346
WBVar00097347
WBVar00097348
WBVar01943116
WBVar02056611
WBVar01602822
WBVar00297958
WBVar01602823
WBVar00297959
WBVar01499416
WBVar00235867
WBVar01499786
WBVar01694723
WBVar00233302
WBVar01430925
WBVar00233303
WBVar01417149
WBVar00233304
WBVar00233305
WBVar01499985
WBVar00233306
WBVar01982072
WBVar01982073
WBVar01982074
WBVar01271139
WBVar01982075
WBVar01982076
WBVar01982077
WBVar01982078
WBVar01762221
WBVar01762222
WBVar02126786
WBVar01421343
WBVar00093152
WBVar01421348
WBVar00304900
WBVar01421351
WBVar01531769
WBVar01531770
WBVar01497432
WBVar01531771
WBVar00624243
WBVar01531772
WBVar00624244
WBVar00624245
WBVar00624246
WBVar00624247
WBVar00624248
WBVar00624249
WBVar00624250
WBVar00624251
WBVar00624252
WBVar00624253
WBVar00624254
WBVar01403117
WBVar00624255
WBVar01403118
WBVar00624256
WBVar00624257
WBVar00329808
WBVar00624258
WBVar01788493
WBVar00329809
WBVar00624259
WBVar00329810
WBVar00329811
WBVar00624260
WBVar00624261
WBVar00329812
WBVar00624262
WBVar00329813
WBVar00624263
WBVar00535779
WBVar00329814
WBVar00624264
WBVar00329815
WBVar01956618
WBVar00624265
WBVar00329816
WBVar01622645
WBVar01988391
WBVar01956620
WBVar00329817
WBVar00624266
WBVar01475193
WBVar01956621
WBVar00624267
WBVar00329818
WBVar01622646
WBVar00624268
WBVar01475194
WBVar01956622
WBVar00329819
WBVar00624269
WBVar01414888
WBVar00329820
WBVar00624270
WBVar00329821
WBVar00329822
WBVar00624271
WBVar00329823
WBVar00624272
WBVar00624273
WBVar00624274
WBVar01414899
WBVar00624275
WBVar00624276
WBVar00624277
WBVar00624278
WBVar00624279
WBVar00624280
WBVar01271250
WBVar00624281
WBVar00624282
WBVar00624283
WBVar00624284
WBVar00624285
WBVar01931868
WBVar01931869
WBVar01931870
WBVar02099977
WBVar01931871
WBVar01931872
WBVar00317425
WBVar02077316
StrainWBStrain00032288
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (44)
Paralog (42)
Structured_descriptionConcise_descriptionnhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis.Paper_evidenceWBPaper00006412
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Molecular_infoCorresponding_CDSC45E1.1a
C45E1.1b
C45E1.1c
Corresponding_CDS_historyC45E1.1a:wp154
C45E1.1b:wp154
Corresponding_transcriptC45E1.1a.1
C45E1.1a.2
C45E1.1b.1
C45E1.1c.1
Other_sequence (44)
Associated_featureWBsf656104
WBsf716912
WBsf717472
WBsf983060
WBsf983061
WBsf983062
WBsf983063
WBsf1009453
WBsf1009454
WBsf217365
Transcription_factorWBTranscriptionFactor000193
Experimental_infoRNAi_result (21)
Expr_patternExpr2866
Expr1017257
Expr1031695
Expr1146511
Expr2014215
Expr2032456
Drives_constructWBCnstr00010996
Construct_productWBCnstr00016569
Microarray_results (25)
Expression_cluster (94)
Interaction (35)
Map_infoMapIPosition-4.47689Error0.002016
PositivePositive_cloneC45E1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4749
Pseudo_map_position
ReferenceWBPaper00006412
WBPaper00027288
WBPaper00027309
WBPaper00036075
WBPaper00038491
WBPaper00044077
WBPaper00055090
WBPaper00059191
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene