WormBase Tree Display for Gene: WBGene00001795

WBGene00001795 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C05C12
  Identity: Version: 1
    Name: CGC_name: gtl-1 Person_evidence: WBPerson51
      Sequence_name: C05C12.3
      Molecular_name: C05C12.3
        C05C12.3.1
        CE33754
      Other_name: tag-33 CGC_data_submission
        CELE_C05C12.3 Accession_evidence: NDB BX284604
      Public_name: gtl-1
    DB_info: Database: AceView gene 4M14
        WormQTL gene WBGene00001795
        WormFlux gene WBGene00001795
        NDB locus_tag CELE_C05C12.3
        Panther gene CAEEL|WormBase=WBGene00001795|UniProtKB=G5ECM4
          family PTHR13800
        NCBI gene 178031
        RefSeq protein NM_069710.6
        TrEMBL UniProtAcc G5ECM4
        UniProt_GCRP UniProtAcc G5ECM4
        OMIM gene 603576
            605692
            608961
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gtl
    Allele (118)
    Strain: WBStrain00003262
      WBStrain00035612
    RNASeq_FPKM (74)
    GO_annotation: 00012064
      00012065
      00012066
      00012067
      00012068
      00012069
    Ortholog (46)
    Paralog: WBGene00001651 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001796 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000425 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004149 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008731 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020972 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021404 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021408 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine. Paper_evidence: WBPaper00005092
            WBPaper00011328
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110867 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7146)
      DOID:0050534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7146)
      DOID:0111246 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17994)
      DOID:83 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17992)
  Molecular_info: Corresponding_CDS: C05C12.3
    Corresponding_CDS_history: C05C12.3:wp99
    Corresponding_transcript: C05C12.3.1
    Other_sequence: FK807706.1
      MHC01321_1
      MH01590
      Dviv_isotig25122
      FM207828.1
    Associated_feature: WBsf668304
      WBsf1018190
      WBsf230849
  Experimental_info: RNAi_result: WBRNAi00010181 Inferred_automatically: RNAi_primary
      WBRNAi00039701 Inferred_automatically: RNAi_primary
      WBRNAi00001394 Inferred_automatically: RNAi_primary
      WBRNAi00001519 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1622
      Expr3713
      Expr5160
      Expr8230
      Expr8232
      Expr1017897
      Expr1031057
      Expr1143801
      Expr2012342
      Expr2030579
    Drives_construct: WBCnstr00003737
      WBCnstr00007204
      WBCnstr00007207
      WBCnstr00007208
      WBCnstr00007209
      WBCnstr00011622
      WBCnstr00013197
      WBCnstr00021190
      WBCnstr00036678
    Construct_product: WBCnstr00011622
      WBCnstr00013197
      WBCnstr00036678
    Microarray_results (18)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_7
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055364:uaf-1(n4588)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:mdt-15(mg584)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061285:wounding_24h_upregulated
      WBPaper00061340:AVJ
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:RID
      WBPaper00061340:RID_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:gtl-1-hum-8_16432
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036286:Pattern_C
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037147:heatshock_downregulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
    Interaction (18)
  Map_info: Map: IV Position: 4.92955 Error: 0.001473
    Positive: Positive_clone: C05C12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4386
        4526
    Pseudo_map_position
  Reference: WBPaper00010099
    WBPaper00011328
    WBPaper00011683
    WBPaper00023556
    WBPaper00024755
    WBPaper00024894
    WBPaper00025331
    WBPaper00026597
    WBPaper00027280
    WBPaper00028115
    WBPaper00029042
    WBPaper00031549
    WBPaper00031896
    WBPaper00035380
    WBPaper00035487
    WBPaper00036046
    WBPaper00036498
    WBPaper00038142
    WBPaper00038410
    WBPaper00038491
    WBPaper00040955
    WBPaper00041112
    WBPaper00045423
    WBPaper00048884
    WBPaper00055090
    WBPaper00059257
    WBPaper00059396
    WBPaper00059520
    WBPaper00064809
  Remark: Sequence connection from Kwan CSM, Ragnauth CD and Baylis HA [021008 ck1]
    Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene