WormBase Tree Display for Gene: WBGene00000396

WBGene00000396 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: cdh-4 Person_evidence: WBPerson698
      Sequence_name: F25F2.2
      Molecular_name: F25F2.2
        F25F2.2.1
        CE51760
      Other_name: CELE_F25F2.2 Accession_evidence: NDB BX284603
      Public_name: cdh-4
    DB_info: Database: AceView gene 3F625
        WormQTL gene WBGene00000396
        WormFlux gene WBGene00000396
        NDB locus_tag CELE_F25F2.2
        Panther gene CAEEL|WormBase=WBGene00000396|UniProtKB=Q19319
          family PTHR24025
        NCBI gene 175590
        RefSeq protein NM_001330837.3
        SwissProt UniProtAcc Q19319
        UniProt_GCRP UniProtAcc Q19319
        OMIM gene 604269
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdh
    Allele: WBVar00092553 Inferred_automatically: From strain object: RB1256
      WBVar00600714 Inferred_automatically: From strain object: VH1940
      WBVar00600713 Inferred_automatically: From strain object: VH29
      WBVar00822311
      WBVar00309886
      WBVar00822312
      WBVar00309887
      WBVar00309888
      WBVar00822313
      WBVar00309889
      WBVar00822314
      WBVar00822315
      WBVar00302679
      WBVar00822316
      WBVar00822317
      WBVar00822318
      WBVar01893263
      WBVar01263091
      WBVar00822319
      WBVar01893264
      WBVar01263092
      WBVar00822320
      WBVar01263093
      WBVar00822321
      WBVar01263094
      WBVar00299763
      WBVar01566330
      WBVar00822322
      WBVar00299764
      WBVar01566331
      WBVar00822323
      WBVar00822324
      WBVar01263096
      WBVar00822325
      WBVar01263097
      WBVar00822326
      WBVar00822327
      WBVar00822328
      WBVar00822329
      WBVar00822330
      WBVar00822331
      WBVar00822332
      WBVar00822333
      WBVar01445325
      WBVar00822334
      WBVar01445328
      WBVar00822335
      WBVar01445330
      WBVar00822336
      WBVar01445331
      WBVar01709985
      WBVar00822337
      WBVar00822338
      WBVar01445333
      WBVar00822339
      WBVar00822340
      WBVar00822341
      WBVar00822342
      WBVar00822343
      WBVar00822344
      WBVar00822345
      WBVar00822346
      WBVar01913276
      WBVar00822347
      WBVar00822348
      WBVar00822349
      WBVar02053238
      WBVar02125748
      WBVar00822350
      WBVar02125749
      WBVar00822351
      WBVar00822352
      WBVar02125750
      WBVar00822353
      WBVar00822354
      WBVar00822355
      WBVar00822356
      WBVar02131897
      WBVar00822357
      WBVar00822358
      WBVar02131898
      WBVar00822359
      WBVar00822360
      WBVar00822361
      WBVar00822362
      WBVar00239266
      WBVar00822363
      WBVar00822364
      WBVar00822365
      WBVar00822366
      WBVar00822367
      WBVar00822368
      WBVar00822369
      WBVar00822370
      WBVar00822371
      WBVar00822372
      WBVar00822373
      WBVar00822374
      WBVar00822375
      WBVar00822376
      WBVar00822377
      WBVar00822378
      WBVar00306556
      WBVar00822379
      WBVar00396160
      WBVar00822380
      WBVar00396161
      WBVar00306557
      WBVar00822381
      WBVar00396162
      WBVar00306558
      WBVar00306559
      WBVar00822382
      WBVar00396163
      WBVar00822383
      WBVar00396164
      WBVar00306560
      WBVar00822384
      WBVar00396165
      WBVar00306561
      WBVar00396166
      WBVar00822385
      WBVar00306562
      WBVar00396167
      WBVar01490758
      WBVar00396168
      WBVar00396169
      WBVar00396170
      WBVar00396171
      WBVar00396172
      WBVar00396173
      WBVar00396174
      WBVar00396175
      WBVar00396176
      WBVar00396177
      WBVar00396178
      WBVar00396179
      WBVar01793409
      WBVar01396744
      WBVar00396180
      WBVar00396181
      WBVar01396746
      WBVar00396182
      WBVar00396183
      WBVar00396184
      WBVar00396185
      WBVar00396186
      WBVar01785480
      WBVar00396187
      WBVar01785481
      WBVar00396188
      WBVar00276408
      WBVar00396189
      WBVar00396190
      WBVar02112968
      WBVar00396191
      WBVar00396192
      WBVar00396193
      WBVar00396194
      WBVar00396195
      WBVar00313077
      WBVar00601379
      WBVar00313078
      WBVar00307869
      WBVar00307870
      WBVar00313079
      WBVar00307871
      WBVar00313080
      WBVar00307872
      WBVar00313081
      WBVar00314723
      WBVar00233685
      WBVar00313082
      WBVar00313083
      WBVar00314724
      WBVar00314725
      WBVar00314726
      WBVar00314727
      WBVar00052171
      WBVar01952148
      WBVar00300956
      WBVar00300957
      WBVar00300958
      WBVar00305348
      WBVar00305349
      WBVar00305350
      WBVar00305351
      WBVar02144216
      WBVar00305352
      WBVar00305353
      WBVar00822270
      WBVar00822271
      WBVar00305354
      WBVar00305355
      WBVar00822272
      WBVar00822273
      WBVar00822274
      WBVar00822275
      WBVar00822276
      WBVar01837463
      WBVar00822277
      WBVar00822278
      WBVar01837464
      WBVar00822279
      WBVar01837465
      WBVar00822280
      WBVar00822281
      WBVar00822282
      WBVar00303273
      WBVar00822283
      WBVar00822284
      WBVar00822285
      WBVar01938958
      WBVar00822286
      WBVar01491027
      WBVar00822287
      WBVar00822288
      WBVar00822289
      WBVar00822290
      WBVar00276290
      WBVar00822291
      WBVar00822292
      WBVar00822293
      WBVar00822294
      WBVar00822295
      WBVar00822296
      WBVar00142602
      WBVar00822297
      WBVar00822298
      WBVar00822299
      WBVar00822300
      WBVar00822301
      WBVar00822302
      WBVar00822303
      WBVar00822304
      WBVar00822305
      WBVar00822306
      WBVar00822307
      WBVar00822308
      WBVar00822309
      WBVar00822310
    Strain: WBStrain00031956
      WBStrain00040005
      WBStrain00040029
      WBStrain00054849
      WBStrain00054848
    RNASeq_FPKM (74)
    GO_annotation: 00107325
      00107326
      00107327
    Ortholog (40)
    Paralog: WBGene00000395 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00019994 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000397 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000399 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000401 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000402 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017576 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022103 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cdh-4 encodes a Fat-like cadherin homolog; CDH-4 is required for axon fasciculation, cell migration, and hypodermis and pharyngeal development; in addition, CDH-4 functions together with the FMI-1 flamingo-like cadherin to regulate development of the GABAergic VD motorneurons; cdh-4 is widely expressed beginning early in development, but by the L3 larval stage expression is confined to the VD GABAergic motorneurons. Paper_evidence: WBPaper00004508
            WBPaper00040906
            WBPaper00031584
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 05 Jul 2012 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Expressed in several structures, including QL; QR; VD neuron; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Is an ortholog of human FAT1 (FAT atypical cadherin 1); FAT2 (FAT atypical cadherin 2); and FAT3 (FAT atypical cadherin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:5409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:0080287 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3596)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
  Molecular_info: Corresponding_CDS: F25F2.2
    Corresponding_CDS_history: F25F2.2:wp196
      F25F2.2a:wp254
      F25F2.2b:wp254
    Corresponding_transcript: F25F2.2.1
    Other_sequence (25)
    Associated_feature (20)
  Experimental_info: RNAi_result: WBRNAi00107683 Inferred_automatically: RNAi_primary
      WBRNAi00087905 Inferred_automatically: RNAi_primary
      WBRNAi00091981 Inferred_automatically: RNAi_primary
      WBRNAi00091983 Inferred_automatically: RNAi_primary
      WBRNAi00091982 Inferred_automatically: RNAi_primary
      WBRNAi00091980 Inferred_automatically: RNAi_primary
      WBRNAi00066038 Inferred_automatically: RNAi_primary
      WBRNAi00045516 Inferred_automatically: RNAi_primary
      WBRNAi00013880 Inferred_automatically: RNAi_primary
      WBRNAi00005086 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00004151
      WBCnstr00011728
      WBCnstr00013074
      WBCnstr00014479
      WBCnstr00037571
    Construct_product: WBCnstr00037571
    Microarray_results (20)
    Expression_cluster (198)
    Interaction (39)
    Anatomy_function: WBbtf0635
      WBbtf0636
  Map_info: Map: III Position: -3.14046 Error: 0.002997
    Positive: Positive_clone: F25F2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4192
        4564
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene