WormBase Tree Display for Gene: WBGene00019994

WBGene00019994 SMap: S_parent: Sequence: R10F2
  Identity: Version: 2
    Name: CGC_name: cdh-1 Person_evidence: WBPerson698
      Sequence_name: R10F2.1
      Molecular_name: R10F2.1
        R10F2.1.1
        CE38097
      Other_name: CELE_R10F2.1 Accession_evidence: NDB BX284603
      Public_name: cdh-1
    DB_info: Database: AceView gene 3E21
        WormQTL gene WBGene00019994
        WormFlux gene WBGene00019994
        NDB locus_tag CELE_R10F2.1
        Panther gene CAEEL|WormBase=WBGene00019994|UniProtKB=Q5F4W0
          family PTHR24026
        NCBI gene 187783
        RefSeq protein NM_065240.3
        TrEMBL UniProtAcc Q5F4W0
        UniProt_GCRP UniProtAcc Q5F4W0
        OMIM gene 603057
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Oct 2005 17:48:07 WBPerson1867 Event: Acquires_merge: WBGene00000394
      Acquires_merge: WBGene00000394
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdh
    Allele (545)
    Legacy_information: [C.elegansII] NMK. Encodes cadherin-related protein. 11 kb embryonic transcript. [BW; NL]cdh-2V18.09NMK. Encodes cadherin-related protein. 11 kb embryonic transcript. [BW; NL]cdh-3III-0.58pk87te : viable, grossly wild type; allele is deletion derived pk77tci. Encodes a cadherin-related protein. 10kb transcript detected on Northern blots, in late-stage embryo and L1 larval RNA. cdh:lac-Z expressed in seam cells, comma-stage through to 3-fold embryos. A few other as yet unidentified hypodermal cells also stain in the anterior. Overexpression of truncated transgene leads to Pun(pharynx detachment) phenotype. [BW; NL]
    Strain: WBStrain00036709
      WBStrain00036773
    RNASeq_FPKM (74)
    GO_annotation: 00081313
      00081314
      00081315
      00081316
      00124719
      00124720
      00124721
    Ortholog (47)
    Paralog: WBGene00000395 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000396 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000397 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000399 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000401 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000402 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017576 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022103 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cdh-1 encodes a cadherin that is similar, in the extracellular domain, to the Drosophila cadherin Dachsous (Ds); although the precise role of cdh-1 in C. elegans development and/or behavior is not yet known, loss of cdh-1 activity via RNAi using the hypersensitive rrf-3 strain can result in locomotion and growth defects, as well as larval lethality. Paper_evidence: WBPaper00004508
            WBPaper00006395
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jan 2006 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Is an ortholog of human DCHS1 (dachsous cadherin-related 1) and DCHS2 (dachsous cadherin-related 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080585 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13681)
      DOID:988 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13681)
  Molecular_info: Corresponding_CDS: R10F2.1
    Corresponding_CDS_history: R10F2.1:wp138
    Corresponding_transcript: R10F2.1.1
    Other_sequence (15)
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00026080 Inferred_automatically: RNAi_primary
      WBRNAi00017722 Inferred_automatically: RNAi_primary
      WBRNAi00006508 Inferred_automatically: RNAi_primary
      WBRNAi00051728 Inferred_automatically: RNAi_primary
      WBRNAi00027439 Inferred_automatically: RNAi_primary
      WBRNAi00051730 Inferred_automatically: RNAi_primary
      WBRNAi00051729 Inferred_automatically: RNAi_primary
      WBRNAi00101844 Inferred_automatically: RNAi_primary
      WBRNAi00026081 Inferred_automatically: RNAi_primary
      WBRNAi00006579 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1029152
      Expr1038682
      Expr1155395
      Expr2009800
      Expr2028040
    Microarray_results (21)
    Expression_cluster (152)
    Interaction (16)
  Map_info: Map: III Position: -8.54738 Error: 0.250728
    Positive: Positive_clone: CH#L2-12
        R10F2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene