WormBase Tree Display for Gene: WBGene00000396

WBGene00000396 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: cdh-4 Person_evidence: WBPerson698
      Sequence_name: F25F2.2
      Molecular_name: F25F2.2
        F25F2.2.1
        CE51760
      Other_name: CELE_F25F2.2 Accession_evidence: NDB BX284603
      Public_name: cdh-4
    DB_info: Database: AceView gene 3F625
        WormQTL gene WBGene00000396
        WormFlux gene WBGene00000396
        NDB locus_tag CELE_F25F2.2
        Panther gene CAEEL|WormBase=WBGene00000396|UniProtKB=Q19319
          family PTHR24025
        NCBI gene 175590
        RefSeq protein NM_001330837.3
        SwissProt UniProtAcc Q19319
        UniProt_GCRP UniProtAcc Q19319
        OMIM gene 604269
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdh
    Allele (241)
    Strain: WBStrain00031956
      WBStrain00040005
      WBStrain00040029
      WBStrain00054849
      WBStrain00054848
    RNASeq_FPKM (74)
    GO_annotation: 00107325
      00107326
      00107327
    Ortholog (40)
    Paralog: WBGene00000395 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00019994 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000397 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000399 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000401 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000402 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017576 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022103 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cdh-4 encodes a Fat-like cadherin homolog; CDH-4 is required for axon fasciculation, cell migration, and hypodermis and pharyngeal development; in addition, CDH-4 functions together with the FMI-1 flamingo-like cadherin to regulate development of the GABAergic VD motorneurons; cdh-4 is widely expressed beginning early in development, but by the L3 larval stage expression is confined to the VD GABAergic motorneurons. Paper_evidence: WBPaper00004508
            WBPaper00040906
            WBPaper00031584
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 05 Jul 2012 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Expressed in several structures, including QL; QR; VD neuron; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Is an ortholog of human FAT1 (FAT atypical cadherin 1); FAT2 (FAT atypical cadherin 2); and FAT3 (FAT atypical cadherin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:5409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:0080287 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3596)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3595)
  Molecular_info: Corresponding_CDS: F25F2.2
    Corresponding_CDS_history: F25F2.2:wp196
      F25F2.2a:wp254
      F25F2.2b:wp254
    Corresponding_transcript: F25F2.2.1
    Other_sequence (25)
    Associated_feature (20)
  Experimental_info: RNAi_result: WBRNAi00107683 Inferred_automatically: RNAi_primary
      WBRNAi00087905 Inferred_automatically: RNAi_primary
      WBRNAi00091981 Inferred_automatically: RNAi_primary
      WBRNAi00091983 Inferred_automatically: RNAi_primary
      WBRNAi00091982 Inferred_automatically: RNAi_primary
      WBRNAi00091980 Inferred_automatically: RNAi_primary
      WBRNAi00066038 Inferred_automatically: RNAi_primary
      WBRNAi00045516 Inferred_automatically: RNAi_primary
      WBRNAi00013880 Inferred_automatically: RNAi_primary
      WBRNAi00005086 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00004151
      WBCnstr00011728
      WBCnstr00013074
      WBCnstr00014479
      WBCnstr00037571
    Construct_product: WBCnstr00037571
    Microarray_results (20)
    Expression_cluster (198)
    Interaction (39)
    Anatomy_function: WBbtf0635
      WBbtf0636
  Map_info: Map: III Position: -3.14046 Error: 0.002997
    Positive: Positive_clone: F25F2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4192
        4564
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene