xrn-2 encodes a 5'-3' exoribonuclease orthologous to Saccharomyces cerevisiae Rat1p; XRN-2 activity is required for degradation and hence regulation of levels of mature miRNAs such as let-7; accordingly, loss of xrn-2 activity affects miRNA-mediated processes such as molting, specifically shedding cuticle from the pharynx, and regulation of vulval development; an xrn-2::gfp promoter fusion is expressed in the pharyngeal myoepithelium, the intestine, and neurons.
Enables 5'-3' RNA exonuclease activity. Involved in several processes, including miRNA catabolic process; negative regulation of miRNA-mediated gene silencing; and regulation of vulval development. Located in nucleus. Expressed in M5 neuron; PVT; intestine; and pharyngeal epithelial cell. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; leiomyosarcoma; and lung cancer. Is an ortholog of human XRN2 (5'-3' exoribonuclease 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.