WormBase Tree Display for Gene: WBGene00012730
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| WBGene00012730 | Evidence | Paper_evidence | WBPaper00006308 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y39G8C | ||||||
| Identity | Version | 3 | |||||||
| Name | CGC_name | xrn-1 | |||||||
| Sequence_name | Y39G8C.1 | ||||||||
| Molecular_name | Y39G8C.1 | ||||||||
| Y39G8C.1.1 | |||||||||
| CE42924 | |||||||||
| Other_name | Y39G8C.b | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y39G8C.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | xrn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 17 Sep 2004 10:21:40 | WBPerson1971 | Name_change | CGC_name | xrn-1 | ||||
| 3 | 18 Jul 2008 16:44:00 | WBPerson1983 | Event | Acquires_merge | WBGene00044055 | ||||
| Acquires_merge | WBGene00044055 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xrn | ||||||||
| Allele (737) | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP2724 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00006964 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | xrn-1 encodes a 5'-3' exoribonuclease that is orthologous to Saccharomyces cerevisiae Xrnp1, a key component of the yeast 5'-3' mRNA degradation pathway; in C. elegans, XRN-1 activity is required during embryogenesis for completion of ventral enclosure, the morphogenetic process whereby the ventral epithelial cells cover and seal the interior cells of the embryo; in addition, XRN-1 also plays a role in facilitating RNA interference (RNAi), likely acting in the same pathway as the DCR-1/Dicer ribonuclease; to date, XRN-1 expression has been reported in adult hypodermal and rectal cells. | Paper_evidence | WBPaper00006308 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable 5'-3' RNA exonuclease activity and RNA binding activity. Involved in determination of adult lifespan and negative regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in nucleus. Expressed in hypodermis and rectum. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human XRN1 (5'-3' exoribonuclease 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30654) | ||||
| Molecular_info | Corresponding_CDS | Y39G8C.1 | |||||||
| Corresponding_CDS_history | Y39G8C.1:wp91 | ||||||||
| Y39G8C.1:wp193 | |||||||||
| Corresponding_transcript | Y39G8C.1.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf990619 | ||||||||
| WBsf990620 | |||||||||
| WBsf990621 | |||||||||
| WBsf1013768 | |||||||||
| WBsf1013769 | |||||||||
| WBsf1013770 | |||||||||
| WBsf222422 | |||||||||
| WBsf222423 | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr2827 | ||||||||
| Expr1028840 | |||||||||
| Expr1035633 | |||||||||
| Expr1159774 | |||||||||
| Expr2018110 | |||||||||
| Expr2036248 | |||||||||
| Drives_construct | WBCnstr00010975 | ||||||||
| Construct_product | WBCnstr00010975 | ||||||||
| Antibody | WBAntibody00002505 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (95) | |||||||||
| Interaction (331) | |||||||||
| Map_info | Map | II | Position | 22.401 | Error | 0.003133 | |||
| Positive | Positive_clone | Y39G8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
