WormBase Tree Display for Gene: WBGene00015574

WBGene00015574 SMap: S_parent: Sequence: C07G3
  Identity: Version: 2
    Name: CGC_name: irg-1 Person_evidence: WBPerson3965
      Sequence_name: C07G3.2
      Molecular_name: C07G3.2
        C07G3.2.1
        CE07993
      Other_name: CELE_C07G3.2 Accession_evidence: NDB BX284605
      Public_name: irg-1
    DB_info: Database: AceView gene 5D999
        WormQTL gene WBGene00015574
        WormFlux gene WBGene00015574
        NDB locus_tag CELE_C07G3.2
        NCBI gene 182379
        RefSeq protein NM_071582.5
        TREEFAM TREEFAM_ID TF316991
        TrEMBL UniProtAcc O16327
        UniProt_GCRP UniProtAcc O16327
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 13 Jul 2009 13:51:47 WBPerson9133 Name_change: CGC_name: irg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: irg
    Allele (37)
    RNASeq_FPKM (74)
    GO_annotation: 00027834
      00027835
      00105960
      00105967
      00105968
    Ortholog (32)
    Paralog: WBGene00007440 Caenorhabditis elegans From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00020747 Caenorhabditis elegans From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00010436 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012927 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012968 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016495 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020052 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: irg-1 encodes a protein containing a conserved DUF1768 domain, a domain of unknown function found as a stand-alone domain in bacterial and bacteriophage proteins as well as fused to proteins involved in riboflavin biosynthesis in bacteria and plants; irg-1 expression is induced in response to infection with pathogenic Pseudomonas aeruginosa, in a manner independent of the p38 MAPK pathway, but dependent upon the ZIP-2 bZIP transcription factor; irg-1 expression is also induced at a low level in response to cadmium exposure, in a manner that is dependent upon pmk-1. Paper_evidence: WBPaper00028789
            WBPaper00035891
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Feb 2010 00:00:00
      Automated_description: Involved in antibacterial innate immune response and defense response to Gram-negative bacterium. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C07G3.2
    Corresponding_transcript: C07G3.2.1
    Other_sequence: CBC16326_1
    Associated_feature: WBsf231582
  Experimental_info: RNAi_result: WBRNAi00040026 Inferred_automatically: RNAi_primary
      WBRNAi00010403 Inferred_automatically: RNAi_primary
    Expr_pattern (5)
    Drives_construct: WBCnstr00005926
      WBCnstr00013591
      WBCnstr00028740
    Construct_product: WBCnstr00020134
      WBCnstr00028740
    Microarray_results (19)
    Expression_cluster: WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049290:rsks-1(sv31)_upregulated
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050193:cec-4(ok3124)_upregulated_L1
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050504:hrp-2(RNAi)_upregulated
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053402:his-3(RNAi)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:clk-1(qm30)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054810:deoxynivalenol_upregulated
      WBPaper00055137:S.maltophilia_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059231:alh-6(lax105)_L4_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_downregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_downregulated_L1
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-9(ok1354)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061081:skpo-1(ok1640)_upregulated_OG1RF
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:AIZ
      WBPaper00061340:Rectal_gland
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061527:C10C5.2-Y58A7A.3
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-amyloid-beta_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_BAG
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_8h_downregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065331:100nM-ivermectin_upregulated
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065560:E.coli-HB101_upregulated_P0
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065841:13_0
      WBPaper00065841:30_0
      WBPaper00065841:106_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066004:ceh-14(ch3)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_23
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00026980:intestine_enriched
      WBPaper00027111:eri-1(mg366)_upregulated
      WBPaper00028482:PA14_upregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:LD_3-day
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040998:nhr-66_regulated
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041876:daf-10(m79)_downreglated
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042067:Cu2+_upregulated_kgb-1_top50
      WBPaper00042067:Cu2+_upregulated_kgb-1_top66
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044535:male_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00050650:mBmkTX_upregulated
      WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
      WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_A
    Interaction (63)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: V Position: -10.3139 Error: 0.017317
    Positive: Positive_clone: C07G3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene