WormBase Tree Display for Gene: WBGene00002981

WBGene00002981 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: ZK593
  Identity: Version: 2
    Name: CGC_name: lgg-2 Person_evidence: WBPerson321
      Sequence_name: ZK593.6
      Molecular_name: ZK593.6a
        ZK593.6a.1
        CE50405
        ZK593.6b
        CE45416
        ZK593.6b.1
      Other_name: atg-8.2 Person_evidence: WBPerson649
        CELE_ZK593.6 Accession_evidence: NDB BX284604
      Public_name: lgg-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Feb 2008 11:29:00 WBPerson2970 Name_change: Other_name: atg-8.2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lgg
    Allele (37)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog: WBGene00062492 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00028316 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00159574 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00153484 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128015 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00227761 Brugia malayi From_analysis: WormBase-Compara
      WBGene00268385 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10931 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14560 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16135 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g12850 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g6902 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g15879 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16138 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18950 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g500 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1420 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-lgg-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g7992 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00007.g503 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_12859 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014019 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02899 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13555 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g24137 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40308900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11720 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00241026 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00275740 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266551 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288869 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-030131-1145 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2232 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:13352 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6838 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:34390 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1915661 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1914693 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621315 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:735183 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00002980 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: lgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan. Paper_evidence: WBPaper00005654
            WBPaper00006070
            WBPaper00031504
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 Mar 2008 00:00:00
      Automated_description: Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
      DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
      DOID:5082 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6838)
  Molecular_info: Corresponding_CDS (2)
    Corresponding_CDS_history: ZK593.6a:wp246
    Corresponding_transcript: ZK593.6a.1
      ZK593.6b.1
    Other_sequence (78)
    Associated_feature (15)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr9088
      Expr11489
      Expr12743
      Expr1019064
      Expr1031381
      Expr1162945
      Expr2013143
      Expr2031375
    Drives_construct: WBCnstr00009398
      WBCnstr00013713
      WBCnstr00019050
      WBCnstr00022725
      WBCnstr00036308
    Construct_product: WBCnstr00009398
      WBCnstr00013713
      WBCnstr00019050
      WBCnstr00022269
      WBCnstr00036308
    Antibody: WBAntibody00002496
      WBAntibody00002979
    Microarray_results (29)
    Expression_cluster: WBPaper00032031:DConiospora_downregulated_cDNA_12h
      WBPaper00032425:down_in_rde-4
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00034761:hlh-30_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_downregulated
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044736:flat_dev_expression
      WBPaper00044857:BAR-1_downregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00050199:hsf-1(ok600)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00058948:PA14_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061527:cdc-42_17192-rab-5_18073
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061651:AIZ_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062590:Aging_upregulated_coelomocyte
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4386_cluster_6_2
      cgc4489_group_17
      WBPaper00025032:cluster_7
      WBPaper00025032:cluster_95
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027722:Microbacterium_nematophilum_upregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp2
      WBPaper00034739:N2moreDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037695:CC_3-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:TA100_down
      WBPaper00040963:TA300_down
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041207:CE_dauer_up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042548:miRISC_enriched
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (120)
  Map_info: Map: IV Position: 4.75551 Error: 0.001217
    Positive: Positive_clone: ZK593 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (48)
  Remark: Sequence connection from [Kimura Y]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene