| WBGene00016204 | SMap | S_parent | Sequence | C29E4 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | gsto-1 | Paper_evidence | WBPaper00031042 |
| | | Sequence_name | C29E4.7 |
| | | Molecular_name | C29E4.7 |
| | | | C29E4.7.1 |
| | | | CE00089 |
| | | Other_name | CELE_C29E4.7 | Accession_evidence | NDB | BX284603 |
| | | Public_name | gsto-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 30 Oct 2007 09:47:18 | WBPerson2970 | Name_change | CGC_name | gsto-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gsto |
| | Allele (25) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00041808 |
| | | 00041809 |
| | | 00041810 |
| | | 00041811 |
| | | 00041812 |
| | | 00041813 |
| | | 00041814 |
| | | 00041815 |
| | | 00041816 |
| | | 00041817 |
| | | 00041818 |
| | | 00041819 |
| | | 00041820 |
| | | 00041821 |
| | | 00041822 |
| | | 00041823 |
| | | 00041824 |
| | | 00041825 |
| | | 00041826 |
| | | 00041827 |
| | | 00041828 |
| | | 00041829 |
| | | 00041830 |
| | | 00041831 |
| | | 00041832 |
| | | 00041833 |
| | | 00041834 |
| | | 00041835 |
| | | 00121884 |
| | | 00121885 |
| | Ortholog (39) |
| | Paralog | WBGene00001792 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00015337 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00043097 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019636 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001365 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00001371 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00001790 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00001791 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008920 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00021817 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site. | Paper_evidence | WBPaper00031042 |
| | | | | | WBPaper00031083 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 16 Oct 2007 00:00:00 |
| | | Automated_description | Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in cellular response to extracellular stimulus; obsolete oxidation-reduction process; and response to superoxide. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) |
| | | DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23064) |
| | | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) |
| Molecular_info | Corresponding_CDS | C29E4.7 |
| | Corresponding_transcript | C29E4.7.1 |
| | Other_sequence | CBC14472_1 |
| | | AF203814.2 |
| | | CJC05775_1 |
| | Associated_feature | WBsf034318 |
| | | WBsf667116 |
| | | WBsf227052 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Expr4883 |
| | | Expr4884 |
| | | Expr1021261 |
| | | Expr1036937 |
| | | Expr1145482 |
| | | Expr2012336 |
| | | Expr2030573 |
| | Drives_construct | WBCnstr00012309 |
| | | WBCnstr00028246 |
| | Construct_product | WBCnstr00012309 |
| | | WBCnstr00028246 |
| | Antibody | WBAntibody00001308 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00036738:4uM_Heme_upregulated |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00040560:hpl-2_L3_upregulated |
| | | WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00042561:smgl-2(RNAi)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045842:elt-2_dependent_hypoxia_upregulated |
| | | WBPaper00045918:96h_infection_recovery_upregulated |
| | | WBPaper00045918:120h_infection_recovery_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049098:heat-repressed_hrde-1(tm1200) |
| | | WBPaper00049736:15deg-then-25deg(12hr)_downregulated_N2 |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049979:R-astaxanthin_upregulated |
| | | WBPaper00050121:mir-60(n4947)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053771:up_at_24h-NaCl |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054796:cav-1(RNAi)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:nuo-6(qm200)_upregulated |
| | | WBPaper00055944:C.butyricum_vs_OP50_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day3 |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057196:raga-1(ok386)_downregulated) |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00059253:sucrose_stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_upregulated |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27) |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060399:CoCl2_6hr_upregulated_N2 |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L1 |
| | | WBPaper00060634:fhod-1(tm2363)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:HB115_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640) |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:XXX |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061527:W07B8.1-C15C8.3 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061590:CGP37157_upregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00062056:dpl-1(n2994)_upregulated |
| | | WBPaper00062078:NMR-HspB1_regulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064130:Beta-Amyloid_8h_upregulated_mRNA |
| | | WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064789:Day9_vs_Day1_downregulated_neuron |
| | | WBPaper00064789:Day12_vs_Day1_downregulated_neuron |
| | | WBPaper00064999:miR-229-64-65-66_upregulated |
| | | WBPaper00065005:sams-3(RNAi)_downregulated |
| | | WBPaper00065005:sams-4(RNAi)_downregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C |
| | | WBPaper00065158:25C_vs_15C_downregulated_AFD |
| | | WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065392:Lb.delbrueckii_upregulated |
| | | WBPaper00065392:Lb.gasseri_upregulated |
| | | WBPaper00065392:Lb.plantarum_upregulated |
| | | WBPaper00065392:Lb.reuteri_upregulated |
| | | WBPaper00065392:Lb.rhamnosus_upregulated |
| | | WBPaper00065392:P.pentosaceus_upregulated |
| | | WBPaper00065560:E.coli-HB101_upregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_1_4 |
| | | cgc4489_group_3 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00029437:rde-4_downregulated |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031703:heme_responsive_2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035891:zip-2(RNAi)_downregulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038231:Cry5B_2-fold_downregulated |
| | | WBPaper00039792:TempShiftIncrease |
| | | WBPaper00039866:ClassComp_daf-19_downregulated |
| | | WBPaper00039866:SAM_daf-19_downregulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040963:TA100_up |
| | | WBPaper00040963:TA200_up |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00042258:HT115_upregulated_YoungAdult |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated |
| | | WBPaper00047021:MWCNT_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo |
| | | WBPaper00053550:daf-19(m86)_downregulated_L1 |
| | | WBPaper00053688:E.faecalis_upregulated |
| | | WBPaper00053688:E.faecium_upregulated |
| | | WBPaper00055899:2,4-Dinitroanisole_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc6390]:Cluster_C |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (15) |
| Map_info | Map | III | Position | -0.473487 | Error | 0.00203 |
| | Positive | Positive_clone | C29E4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00024841 |
| | WBPaper00031042 |
| | WBPaper00038491 |
| | WBPaper00042271 |
| | WBPaper00045842 |
| | WBPaper00055090 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
